what going on now? i eat regularly because it's part of my person list of drug rules and among the very top ones are NEVER MISS A MEAL, infact yes with the instant release meds you'll experience less effect, may i suggest while this may be considered ill-advised, theyre IR anyways right, so try crushing them, also the type of food MATTERS. is it greasy/buttery ? it'll coat the stomach and thus not as much will be absorbed so quickly and more will be absorbed/processed via the liver instead, oxycodone i find is absorbed very very quickly in the stomach and then a portion in the liver, which creates the metabolites among them being Oxymorphone which is a potent painkiller, but you might be too used to the 'immediate' relief you've beeen getting, the goal is relief period. now that may be one form or another, but what dose are you on ? 80 and up shouldn't be crushed if you dont know how your body will deal with it. However. if youve doubled up in the past, then crushing a single tablet won't kill you persay. but do be careful, please put your life ahead of the pain relief even though and i know it all too well, the relief can be the only thing that makes like worth living, but in the end, theres nothing we can do about the pain but we can learn to cope, you shouldnt expect to be pain free, nah. simply comfortable and capable of going about daily life is the main goal, thats what a physician aims toward atleast.
Are you asking this question pertaining to OIC(opioid induced constipation?) if you rather talk in private feel free to message me, i can direct you how to easily solve these issues without pouring blood out of your ass like i have on one occasion that i must say, freaked me the fuck out, i shit you not i thought i was dying. if this is the reason you believe you may be having issues, we will discuss it, while i can assure you i've maintained high-dose pain managment for years without any complications, and my mother has been taking 300mg mscontin for over a decade and she;s more regular than me, it really pisses me off because she boasts about it hrmhrm