so both 5HT1Ar antagonists and an oxytocin receptor antagonist prevented prosocial effects of MDMA (http://www.ncbi.nlm.nih.gov/pubmed/17383105). seems plausible that this OX release is key in the entactogen effects... MDMA raises CENTRAL levels of oxytocin too so i guess it settles it
though the indirect activation of the 1A receptors and further OX release apparently isn't sufficient for the entactogen effects*, as seen with anedoctal reports on selective and selective-ish 5HT releasing agents being uninteresing... catecholamine release is necessary too, and i remember sekio mentioning preventing NE release from MDMA prevented its effects...
is it correct to think that NE plays an important role in the effects? probably something with the amygdala i'd guess (just found a promising paper about NE in the amygdala and fear extinction... the content will probably be beyond my comprehension though)
how could whatever NE is doing the amygdala connected to the oxytocin release? because, y'know i don't think NE releasers alone would be helpful in e.g. fear extinction training
and: * i wonder what 8-OH-DPAT feels like. someone try it already!!!
oh boy, MDMA seems like one HELL of a serendipitous drug, i mean, if in history humans were trying to find something like it through intelligent drug design...
though the indirect activation of the 1A receptors and further OX release apparently isn't sufficient for the entactogen effects*, as seen with anedoctal reports on selective and selective-ish 5HT releasing agents being uninteresing... catecholamine release is necessary too, and i remember sekio mentioning preventing NE release from MDMA prevented its effects...
is it correct to think that NE plays an important role in the effects? probably something with the amygdala i'd guess (just found a promising paper about NE in the amygdala and fear extinction... the content will probably be beyond my comprehension though)
how could whatever NE is doing the amygdala connected to the oxytocin release? because, y'know i don't think NE releasers alone would be helpful in e.g. fear extinction training
and: * i wonder what 8-OH-DPAT feels like. someone try it already!!!
oh boy, MDMA seems like one HELL of a serendipitous drug, i mean, if in history humans were trying to find something like it through intelligent drug design...