Etizolam has a short T1/2 but not too much a1 affinity. I was sent 100mg of etizolam and asked 'IS THIS ETIZOLAM' so I swallowed it all, walked down town, did some shopping, posted a letter, bought my wife some flowers and walked home....
YES I could feel it, but I suspect it has a plateau beyond which more will not do more. BTW I'm not bragging, it was a f**king stupid thing to do but nobody noted that I was intoxicated.
But imagine if it had been say 10mg of flunitrazolam? I might have woken up in a hospital or a prison cell.... and in either case, IF you have a monster benzo habit, neither place is going to offer much help. It's things like that people forget. The term 'hooked' means that a sharp, painful object is causing you pain and the further away you walk, the more painful it will become...
Phenobarbitone is VERY likely to be the drug used to treat the dependent. I HAVE designed something better. Tell me your thoughts.
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The compound is norflubromazepam with an N-propanoyl moiety making it a prodrug. Over 12 hours the N-propanoyl will undergo hydrolysis so given once daily, it will keep the plasma level of the active metabolite very, very steady. I think their ARE some benzos with an N-acetyl but this is slower AND I have gone for a benzodiazepine that is classed as a 'super-agonist'.
So just like people having to pick up methadone and drink it in front of the pharmacist (supervised consumption), so this is readily soluble in propylene glycol and so 1mg/mL or 5mg/mL or even 10mg/mL are all quite possible. Un like methadone where over 24 hours the plasma levels rise for 2.5-4 hours as it is absorbed and then slowly drop back, this will be solid and given the long duration of the active (3 days), even when the dose is dropped, you won't actually feel ANYTHING for 24+ hours.
I should also add that since the onset is slow and the duration very long, it won't be euphoric and (hopefully) it will be of no interest to people seeking to get high off benzos...
Just to be clear - I didn't engineer this crisis to profit from a design. It isn't patented and nor can it be - so ANY generic drug maker can produce it and given that the cost is about $6000/Kg (based on Pharma Compass pricing), someone needing 50mg/day should only pay about 35 cents....