A warning
I am a believer in the
Enone hypothesis of Ketamine bladder damage. Basically, if you take ketamine the major metabolite in urine is dehydronorketamine. Dehydronorketamine contains the
Cyclohexenone functional group, which is a reactive, alkylating irritant toxin because of its contained enone group. Passing hundreds of milligrams of this irritant poison regularly through the bladder is probably the main cause of ketamine bladder toxicity, especially as arylcyclohexylamine metabolites tend to penetrate the bladder wall.
3-MeO-PCP doesn't produce any enone metabolites. Not any. On top of that, the number of milligrams typically consumed is considerably less as of ketamine. So if the enone hypothesis holds true as the cause of ketamine bladder toxicity then no, 3-MeO-PCP will not cause that issue.
Another very related molecule is PCP, its extremely close to 3-MeO-PCP. PCP doesnt cause significant bladder toxicity, but abuse of it DOES cause kidney toxicity, so likely this is the case with 3-MeO too, probably no bladder toxicity but risk of kidney toxicity upon abuse.
I managed to somehow do something to my bladder using 2-oxo-pce/O-PCE this last summer. I never used high doses, probably in the range of 10mg (I'm afraid I can't really say as I eyeballed the doses, but I've never been one to require or want huge amounts of dissociatives anyway). This I think coincided with mild Etizolam withdrawal symptoms (I used it on and off - about 2mg every 2-3 days for several months). I've always had issues with my bladder (started out with a "shy bladder" as a 10-year old, couldn't pee in front of others, still can't). Adding to that I've started to develop what they call CPPS (chronic pelvic pain syndrome) at the age of about 15. I didn't know the diagnosis for sure until I was 23.
Anyway, because of these problems, I think that my bladder/urinary tract (and prostate) is particularly vulnerable to any drug induced side effects.
I admit, I did take the O-PCE daily for a while (2-3 weeks maybe), but like I said, I kept doses pretty low. At some point, I started having difficulties urinating which made me reeeeaally paranoid (I think due to the Etizolam withdrawal making me excessively worry about my health). I started having this constant pressure in my bladder area which made me even more paranoid. I also started having to urinate more often than usual; my bladder didn't seem to hold quite as much as it used to.
It was enough to make me stop using (luckily), but one evening (perhaps a day or two after my last dose) the feeling of pressure was so distressing that I went to the hospital where they did an ultrasound of the bladder. The doctor said that my bladder wall had thickened, I never mentioned any drugs except for "Benzos" to her due to the stigma, as Ketamine and similar drugs aren't very common at all over here.
From this time onwards, I've had mild urinary incontinence: It's like whenever I pee, not all urine gets expelled, a tiny bit stays inside and as soon as I get up (I pee sitting down because I'm lazy) and walk around/sit back down somewhere, it'll come out. It's not much, but it's annoying and embarrassing as hell at my age. This never got better, even after seizing use of any dissociatives for months.
I never had problems like this with Methoxphenidine (which I really like/d). Unfortunately, recently I've found out that my vendor has stopped selling MXP due to it's low popularity.
Sooo, looking for a bladder-friendly substitute, or rather an alternative, I came across 3-MeO-PCP. I tried it for the first time last night (a small amount of 5-10mg, probably closer to 5mg, however I can't say, as again, I eyeballed the dose), and didn't have any problems at first.
However later in the evening I began experiencing this mild pressure in the area of my bladder again. This is pretty disappointing for me as it looks like I'll have to quit taking any dissociatives (which have become my favourite class of drugs and sort of helped me stay abstinent from opioids).
I mean even after not taking any dissociatives for months, and then taking a small dose of the 3-MeO-PCP, I noticed these symptoms, albeit mild ones.
This morning I noticed a very mild stinging sensation in my bladder. There doesn't seem to be any blood in my urine which I'm glad about.
But I just wanted to let people know that it seems like 3-MeO-PCP isn't much better than O-PCE or probably even Ketamine in regards to it's effects on the bladder. The small dosages don't seem to have anything to do with it either, not for me anyway.
Again, I'll stress that I've had a long history of psychosomatic bladder symptoms, so I'm probably kinda predisposed and vulnerable towards any negative effects cause by these substances. But let this still be somewhat of a warning to people. Like I said, my bladder never recovered, even after months of abstinence, and believe me, it's not something you want to experience. I'm just glad I stopped when I did and didn't take it further.
Edit: I'll try a similar dose tonight, and if my symptoms get any worse, I'll probably flush the remainder of it.
If anyone has any idea on how to reduce the toxicity (drink more water than usual to dilute urine?), please let me know.
Also, sorry for reviving an old thread, but I thought it'd be better than creating one of it's own.