JessFR
Bluelight Crew
- Joined
- Oct 22, 2012
- Messages
- 14,706
Well, here's my understanding.
Ok so, say you're a heroin addict. If you take it after 24 hours, much of the heroin in your system will have worn off, and you'll be in withdrawel. The buprenorphine will take effect resulting in a net increase in opioid activity in your system, making you feel better.
If however you don't wait the 24 hours, the buprenorphine will strip the heroin off your system and replace it with itself, since bup is a much weaker partial agonist as opposed to a strong full agonist like heroin, your system experiences a sudden and significant decrease in opioid activity.
I believe it's the sudden shock reduction in opioid activity that causes the preciptated withdrawel. If you wait the 24 hours, you'll have started to go into withdrawel but your body will have had time to adjust.
As you experience withdrawel, your body is adjusting and will eventually recover. At 24 hours you've had 24 hours for your system to adjust. With preciptated withdrawel, your body goes into a significant level of withdrawal almost immediately.
This is how it works to the best of my understanding, in terms of why it makes a difference and why how you feel is so different if you wait the 24 hours or not.
I hope I understood your question and I hope this helps understand the difference.
Ok so, say you're a heroin addict. If you take it after 24 hours, much of the heroin in your system will have worn off, and you'll be in withdrawel. The buprenorphine will take effect resulting in a net increase in opioid activity in your system, making you feel better.
If however you don't wait the 24 hours, the buprenorphine will strip the heroin off your system and replace it with itself, since bup is a much weaker partial agonist as opposed to a strong full agonist like heroin, your system experiences a sudden and significant decrease in opioid activity.
I believe it's the sudden shock reduction in opioid activity that causes the preciptated withdrawel. If you wait the 24 hours, you'll have started to go into withdrawel but your body will have had time to adjust.
As you experience withdrawel, your body is adjusting and will eventually recover. At 24 hours you've had 24 hours for your system to adjust. With preciptated withdrawel, your body goes into a significant level of withdrawal almost immediately.
This is how it works to the best of my understanding, in terms of why it makes a difference and why how you feel is so different if you wait the 24 hours or not.
I hope I understood your question and I hope this helps understand the difference.