User145667
Bluelighter
- Joined
- May 30, 2019
- Messages
- 154
If I got Prolonged QT interval symptoms from mixing Lexapro and Suboxone, is it likely that the same will happen if I mix Methadone with Lexapro?
Are you sure about that?Methadone can also produce long-QT in certain individuals, but it appears to be levomethadone that is responsible. So levomethadone has no advantages.
Are you sure about that?
Every reference I've come across states that dextromethadone is several times more effective at blocking hERG potassium channels than levomethadone...
"LevoMTD's weaker ability to interact with hERG channels and, as a result, its weaker association with QTc prolongation and TdP, have been confirmed by the observation that 90% of patients receiving MTD treatment with a QTc prolongation underwent a normalization of the QT value (<470ms in men and <480ms in women) after switching from MTD to levoMTD."
"LevoMTD's weaker ability to interact with hERG channels and, as a result, its weaker association with QTc prolongation and TdP, have been confirmed by the observation that 90% of patients receiving MTD treatment with a QTc prolongation underwent a normalization of the QT value (<470ms in men and <480ms in women) after switching from MTD to levoMTD."