Pulmonary Edema and the codone family

[C_Tripper]

Hey all.

So, IV administration of a lot of the drugs in the *codone family (Codeine, Hydrocodone, and others) is contraindicated, due to the histamine release (which is much higher than the morphone family) having a very high chace of causing pulmonary edema.

Two questions:
1. What is the exact mechanism that causes the much higher risk factor compared to the morphones? Why does the changed 3-position have this effect, or is it because of some other change?
2. Why is Oxycodone not contraindicated in this way?

Cheers!

 

[Tryptamite]

I know clinically hydrocodone is not used via IV but I was under the impression it could be IVed and wasn't as risky as codeine. I believe Adder said it was possible.

Also didn't Burroughs talk about shooting dihydrocodeine? I know in "Junky" he shot codeine once and had a very bad reaction.

Someone please correct me if I am wrong, I am in no way sure about these statements.