are not anywhere near as euphoric as LSD or mescaline. MDMA, though pretty euphoric, is quite pedestrian in that it doesn't realy transport you to another reality. Ketamine may do that, but then again, it lowers your awareness so you don't enjoy it as much as you could. LSD mescaline and ayahuasca are the only substances i know, that will transport you to another reality, in a state of euphoria and bliss, while being hyper aware of what's going on. What more could a person want from a psychedelic substance?