WSH
Bluelighter
- Joined
- Nov 30, 2012
- Messages
- 360
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As you can see, ketamine reduces depression at sub-anesthetic doses (10mg/kg) but not at anesthetic doses (80mg/kg).
You might say: "but 10mg/kg -> 750mg IM is anesthetic in a 75kg-human!"
I might reply: "but with allosteric scaling (using the factor 8x) 10mg/kg is 10mg/kg /8 *75kg = ~94mg IM which is perfectly sub-anesthetic, wheras 80mg/kg /8 *75kg = 750mg which is almost the exact usual anesthetic dose of ~600mg IM!"
As you can see, ketamine reduces depression at sub-anesthetic doses (10mg/kg) but not at anesthetic doses (80mg/kg).
You might say: "but 10mg/kg -> 750mg IM is anesthetic in a 75kg-human!"
I might reply: "but with allosteric scaling (using the factor 8x) 10mg/kg is 10mg/kg /8 *75kg = ~94mg IM which is perfectly sub-anesthetic, wheras 80mg/kg /8 *75kg = 750mg which is almost the exact usual anesthetic dose of ~600mg IM!"