JohnMonsour
Greenlighter
- Joined
- Nov 10, 2011
- Messages
- 14
Just curious. I have been injected with lorazepam in the emergency room for agitation from benzodiazepine withdrawal. And I swore it had to be soluble in water but it isn't to my dismay. I learned that midazolam is the only water soluble benzo. So my question is: how exactly do the hospitals have ampule upon ampule of this benzodiazepine. I know they are produced in high tech labs and formulated by chemists. There has to be a method to safely prepare lorazepam for intervenious use. We just need the chemistry procedure they use to make the amps for IV use in an emergency setting. And also I have a question. Since the ratios of solubility for lorazepam are best yielded using ethyl alcohol like "ETHYL ALCOHOL DENATURED 200 PROOF" and water at a 50/50 ratio of distilled sterile water and use according to the solubility ratio quoted from above: "n water with 60% ethanol: ~17mg/ml" that allows for minimal alcohol use for highest mg yield per ml of liquid. It says 60% but in my opinion 100% ethyl alcohol would allow you to use roughly 40% less alcohol per ml. Alcohol and water evaporate at room temperature. I don't know the boiling point that would destroy the dissolved lorazepam. But medium heat such as 120° to 150° should be adequate to evaporate the water and alcohol solution leaving behind pure dissolved lorazepam that would be a white crystalline powder. My question is: could you take that powdered lorazepam since it's already been dissolved in a solution and add it to 1 ml of sterile water. Since it's already been solulated into a pure form that would be soluble in sterile water especially if you vigorously shake the prepared solution. Or would it just be straight pure lorazepam and still insoluble in an aqueous solution. Just a thought.