I've taken a lot of gabapentin (prescribed @2400mg/day for 10+ years off and on) and a fair amount of pregabalin, and gabapentin has 100% lost all of it's magic to me; I take it mostly at prescribed doses for anxiety. Even when I've taken breaks from it, it's nowhere near as good as those first few times, or even first few months; I would have to take upwards of 6g over the course of like 5-6 hours to get any kind of buzz from it these days, unfortunately.
Pregabalin on the the other hand is still a pretty good time at 600mg for me, but still not comparable to the first few times.
I guess to an extent that's every drug right?
Maybe it's because I've been harder on my GABA receptors, but the development of tolerance and "loss of magic" associated with GABAergics compared to other drugs is WILD to me.
Once again, it may be just me. idk