Does anyone know of anyone potentiating amphetamine by inhibiting dopamine beta hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine? Clinical results are a mixed bag and usually are presented from the point of view of addiction . But they are interesting:
source
mixed bag, but the article's written from the point of view of addiction medicine
which is why experience reports would be kind of nice if anyone knows of someone whose combined amp with an effective DBH inhibitor.
thanks
Disulfiram inhibits dopamine β-hydroxylase (DBH), the enzyme that converts DA to NE (Karamanakos et al., 2001; Vaccari et al., 1996). As a result, synaptic NE levels decrease relative to DA . . .
Disulfiram’s efficacy for amphetamine addiction has not been examined until recently. Disulfiram enhanced both amphetamine induced pleasurable (“high” and “drug liking”) as well as unpleasant (“anxious” and “bad drug effects”) subjective effects, but did not affect d-amphetamine-induced increases in heart rate or blood pressure (Sofuoglu et al., 2008b). Disulfiram, through inhibition of the enzyme dopamine β-hydroxylase, may increase the amount of dopamine in the brain by blocking dopamine’s conversion to norepinephrine and thereby increasing the amount of dopamine that amphetamine can release (Karamanakos et al., 2001). The active release of dopamine from noradrenergic neurons terminating on the nucleus accumbens would likely increase amphetamine’s positive and negative subjective effects, as observed. From a treatment perspective, although disulfiram might reduce amphetamine abuse by amplifying amphetamine-induced anxiety and “bad drug effects”, making the experience aversive in the same way it does the experience of alcohol intoxication, it might also increase abuse potential by enhancing “high” and “craving”. How these disulfiram-induced increases in both positive and negative subjective responses to amphetamine affect actual drug use remains to be determined empirically in future studies.
source
mixed bag, but the article's written from the point of view of addiction medicine
which is why experience reports would be kind of nice if anyone knows of someone whose combined amp with an effective DBH inhibitor.
thanks