I looked up for the chemical "Salsolinol", which is a potent natural dopamineric neurotoxin and occurs in chocolate in very small amounts (5 micrograms/g) and is even produced endogenous by the addition of pyruvate or formal-/acetaldehyde to dopamine, but usually only in very small amounts.
My question is: When you drink alcohol, it is metabolized to acetaldehyde in quite large amounts, and acetaldehyde should also occur in the brain then and actually react with Dopamine to Methylsalsolinol and therefore cause neurotoxic effects to dopamineric neurons. Could my theory be right?
My question is: When you drink alcohol, it is metabolized to acetaldehyde in quite large amounts, and acetaldehyde should also occur in the brain then and actually react with Dopamine to Methylsalsolinol and therefore cause neurotoxic effects to dopamineric neurons. Could my theory be right?