JohnBoy2000
Bluelighter
- Joined
- May 11, 2016
- Messages
- 2,468
You know with SSRI's - people may try two or three, before they find one that works.
Even though they essentially share the same mechanism of action - SER transporter blockade - right?
Of course each has varying secondary characteristics - prozac - the 5HT2c blockade, zoloft - a slight DRI, the one with the cholinergic properties etc.
But - the fact remains that, someone may not tolerate an SSRI will, switch, and do better on the next - right?
Well - can the same be applied to an NRI?
If a high dose is inducing sedation/anxiety - let's say, desipramine, does it stand to pharmacological reasoning and clinical experience that, perhaps a differnt NRI, say, Reboxetine - might incite a more favorable response in said patient?
Even though they essentially share the same mechanism of action - SER transporter blockade - right?
Of course each has varying secondary characteristics - prozac - the 5HT2c blockade, zoloft - a slight DRI, the one with the cholinergic properties etc.
But - the fact remains that, someone may not tolerate an SSRI will, switch, and do better on the next - right?
Well - can the same be applied to an NRI?
If a high dose is inducing sedation/anxiety - let's say, desipramine, does it stand to pharmacological reasoning and clinical experience that, perhaps a differnt NRI, say, Reboxetine - might incite a more favorable response in said patient?