GlutamateTheory
Greenlighter
- Joined
- Apr 13, 2019
- Messages
- 22
I've looked how DMT binds to different receptors and I find it very interesting.
(I'm self learned mostly so please correct me)
This is from wikipedia and there's a source for it. Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens
DMT also binds to sigma receptors and it is an agonist. It's not in the list but it's in the text.
Up from down: serotonin receptors, dopamine receptors, alpha or adrenergic receptors, TAAR receptor (full name?), histamine receptor 1, serotonin transporter, dopamine transporter and noradrenaline transporter.
Wikipedia link for pharmacodynamics: Wikipedia
So I'm going to ramble here and tell my thoughts. Nothing scientific. I'm just so interested.
What I find interesting is the Histamine 1 binding that is on par with serotonin binding. So it should make you sleep but there's so much stimulation at the same time so it's cancelled maybe.
Don't know exactly how TAAR1 binding affects the experience.
Sigma receptor binding maybe affects the psychedelic part of DMT. That's just my thought. If you look at dissociatives, almost all bind to sigma receptors. In the DXM fact it's theorized that part of the DXM's psychedelia is made by sigma binding. So
that's where I got this thought. The function of sigma receptors is unknown. At least what I read.
5-HT1a agonism is associated with serotonin, dopamine release. 2a and 2c is associated with the psychedelic effects.
I'm going to stop now. I might be spreading lots of misinformation lol.
What do you think?
5-HT1A | 0.075 |
5-HT2A | 0.237 |
5-HT2C | 0.424 |
D1 | 6 |
D2 | 3 |
D3 | 6.3 |
α1A | 1.3 |
α2A | 2.1 |
TAAR1 | 2.2 |
H1 | 0.22 |
SERT | 6 |
DAT | 22 |
NET | 6.5 |
(I'm self learned mostly so please correct me)
This is from wikipedia and there's a source for it. Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens
DMT also binds to sigma receptors and it is an agonist. It's not in the list but it's in the text.
Up from down: serotonin receptors, dopamine receptors, alpha or adrenergic receptors, TAAR receptor (full name?), histamine receptor 1, serotonin transporter, dopamine transporter and noradrenaline transporter.
Wikipedia link for pharmacodynamics: Wikipedia
So I'm going to ramble here and tell my thoughts. Nothing scientific. I'm just so interested.
What I find interesting is the Histamine 1 binding that is on par with serotonin binding. So it should make you sleep but there's so much stimulation at the same time so it's cancelled maybe.
Don't know exactly how TAAR1 binding affects the experience.
Sigma receptor binding maybe affects the psychedelic part of DMT. That's just my thought. If you look at dissociatives, almost all bind to sigma receptors. In the DXM fact it's theorized that part of the DXM's psychedelia is made by sigma binding. So
that's where I got this thought. The function of sigma receptors is unknown. At least what I read.
5-HT1a agonism is associated with serotonin, dopamine release. 2a and 2c is associated with the psychedelic effects.
I'm going to stop now. I might be spreading lots of misinformation lol.
What do you think?