Perampanel - Wikipedia
Doesn't it make perfect sense to try a glutamate antagonist to treat HPPD or visual snow? It sounds like a lot of people on HPPDOnline, HPPD/Visual Snow subreddit think glutamate plays a big role in these disorders. I think it makes sense to look into AMPA antagonists since most NMDA antagonists have been explored. AMPA antagonists are somewhat new. There is one anecdote of someone 90% curing their HPPD with Perampanel. I'm really surprised no one has really looked into this any further.
A big reason this looks so appealing to me is because Piracetam is actually what gave me Visual Snow. Before Piracetam I only had some HPPD symptoms but not much static/snow. Piracetam is a modulator of the AMPA receptor. Piracetam has been known to worsen visual snow and have a strong effect on vision.
Another interesting tidbit. This similar drug (AMPA receptor antagonist) is known for effecting vision in a big way:
Fanapanel - Wikipedia
"side effects thought to be caused by blockade of AMPA receptors in the retina.[4] "
What if my AMPA receptors in my retina are on overdrive and just need to be turned off a bit? Am I possibly on to something? I think it would probably be hard to get Perampanel off label...
(1) A novel Medication which 90% cured my severe HPPD : HPPD (reddit.com)
Perampanel/Fycompa - a novel anti-epileptic drug that pretty much cured my HPPD. - Medications & Other Treatments - Hallucinogen Persisting Perception Disorder (HPPD) Support Forum (hppdonline.com)
https://www.hppdonline.com/topic/9154-ampa-hppd-and-treatment-options-some-glia-thrown-in-too/
/r/visualsnow/comments/pbicsh/study_from_2020_that_found_higher_levels_of/
Doesn't it make perfect sense to try a glutamate antagonist to treat HPPD or visual snow? It sounds like a lot of people on HPPDOnline, HPPD/Visual Snow subreddit think glutamate plays a big role in these disorders. I think it makes sense to look into AMPA antagonists since most NMDA antagonists have been explored. AMPA antagonists are somewhat new. There is one anecdote of someone 90% curing their HPPD with Perampanel. I'm really surprised no one has really looked into this any further.
A big reason this looks so appealing to me is because Piracetam is actually what gave me Visual Snow. Before Piracetam I only had some HPPD symptoms but not much static/snow. Piracetam is a modulator of the AMPA receptor. Piracetam has been known to worsen visual snow and have a strong effect on vision.
Another interesting tidbit. This similar drug (AMPA receptor antagonist) is known for effecting vision in a big way:
Fanapanel - Wikipedia
"side effects thought to be caused by blockade of AMPA receptors in the retina.[4] "
What if my AMPA receptors in my retina are on overdrive and just need to be turned off a bit? Am I possibly on to something? I think it would probably be hard to get Perampanel off label...
(1) A novel Medication which 90% cured my severe HPPD : HPPD (reddit.com)
Perampanel/Fycompa - a novel anti-epileptic drug that pretty much cured my HPPD. - Medications & Other Treatments - Hallucinogen Persisting Perception Disorder (HPPD) Support Forum (hppdonline.com)
https://www.hppdonline.com/topic/9154-ampa-hppd-and-treatment-options-some-glia-thrown-in-too/
/r/visualsnow/comments/pbicsh/study_from_2020_that_found_higher_levels_of/
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