MagickalKat777
Bluelight Crew
- Joined
- Feb 4, 2004
- Messages
- 7,020
I've just now learned of the so-called "holiday heart" and realized that I have PAF. I'm well aware of the drugs and the mortality associated with them. It only takes one beer to trigger it with me but after about 7 or 8 it's gone until the next day where I get all the signs of CGF including being unable to catch my breath and the tachycardia. My question is... I've heard that cayenne pepper can stop tachycardia and even a heart attack in its tracks. So I ordered two pounds of cayenne (which I love anyway so it's not a big deal) but my curiosity lies in the fact that what I've been able to find shows no mechanism of action for cayenne pepper, specifically capsaicin, to be able to not only stop arrhythmias but actually prevent them. I'm curious if all these years of panic attacks could be PAF and that the reason why I could never get off of benzodiazepines is not because of GABA down regulation but because of benzodiazepines, even in the low dose I'm on (20mg of diazepam a day), hitting something that counteracts PAF. See, I can take 5mg of Klonopin and I don't feel anything except for the fact I'm tired. No anxiety relief. Xanax actually makes my PAF worse to where I can feel a "skip" every other beat when it hits me. The same goes for etizolam but curiously flubromazepam has the same calming effect on PAF as Valium does. Obviously it takes longer than Valium but when it hits, my heart goes back to a normal rhythm rather quickly.
So here is the question. Does anyone know the link between capsaicin, diazepam, and flubromazepam that stops PAF in its tracks? I mean let's face it. I've been on 20mg of diazepam since 2010. Before that I reached 6mg of clonazepam and before that 8mg of alprazolam. The curious thing is that I was on 3mg of clonazepam for 3 years yet I was able to cut over to 60mg of diazepam and taper that down over the course of a month to 20mg and I've been stable on that dose for 5 years.
Studies have shown cayenne pepper to stop PAF within 10 minutes, diazepam doesn't hit for about 15 but has a calming effect on PAF. Clonazepam has no effect, alprazolam has a worsening effect, and etizolam is just too inconsistent and flubromazepam takes long enough that the PAF could have resolved on its own.
I should note that marijuana triggers PAF in me too, even high CBD strains like Harlequin, which marijuana is known to trigger PAF episodes through some totally unknown mechanism.
So what is it that cayenne and diazepam are doing that nothing else does? It can't be a metabolite of diazepam because 15 minutes just isn't long enough to have the liver process it. Also the fact that a single alcoholic drink can trigger it suggests that it has something to do with GABA, NMDA, or related systems. Does capsaicin have any receptor affinities shared with any of those three systems even through indirect activation?
My ECG shows up clean but PAF has to be diagnosed with a holter which unfortunately I can't wear because of my static mechanical allodynia going nuts. Plus they would push drugs or surgery and neither is an option.
There is one other interesting fact to add. MDMA does not trigger it but cathinones, mephedrone and methylone in particular do and all phenethylamines except 2C-D and mescaline do as well. Mescaline being a beta blocker doesn't surprise me. Caffeine triggers it 100% of the time and all atypical antipsychotics trigger it that I've been on except Geodon. The pharmacist who works with my psychiatrist ran down the list of drugs that trigger tachycardia with me and realized all of them have M2 action but I'm not aware of muscarinic involvement when it comes to cannabis or benzodiazepines to any significant extent so I'm well and truly stumped but if I can solve this equation, I may be able to finally solve the anxiety and panic attacks.
So here is the question. Does anyone know the link between capsaicin, diazepam, and flubromazepam that stops PAF in its tracks? I mean let's face it. I've been on 20mg of diazepam since 2010. Before that I reached 6mg of clonazepam and before that 8mg of alprazolam. The curious thing is that I was on 3mg of clonazepam for 3 years yet I was able to cut over to 60mg of diazepam and taper that down over the course of a month to 20mg and I've been stable on that dose for 5 years.
Studies have shown cayenne pepper to stop PAF within 10 minutes, diazepam doesn't hit for about 15 but has a calming effect on PAF. Clonazepam has no effect, alprazolam has a worsening effect, and etizolam is just too inconsistent and flubromazepam takes long enough that the PAF could have resolved on its own.
I should note that marijuana triggers PAF in me too, even high CBD strains like Harlequin, which marijuana is known to trigger PAF episodes through some totally unknown mechanism.
So what is it that cayenne and diazepam are doing that nothing else does? It can't be a metabolite of diazepam because 15 minutes just isn't long enough to have the liver process it. Also the fact that a single alcoholic drink can trigger it suggests that it has something to do with GABA, NMDA, or related systems. Does capsaicin have any receptor affinities shared with any of those three systems even through indirect activation?
My ECG shows up clean but PAF has to be diagnosed with a holter which unfortunately I can't wear because of my static mechanical allodynia going nuts. Plus they would push drugs or surgery and neither is an option.
There is one other interesting fact to add. MDMA does not trigger it but cathinones, mephedrone and methylone in particular do and all phenethylamines except 2C-D and mescaline do as well. Mescaline being a beta blocker doesn't surprise me. Caffeine triggers it 100% of the time and all atypical antipsychotics trigger it that I've been on except Geodon. The pharmacist who works with my psychiatrist ran down the list of drugs that trigger tachycardia with me and realized all of them have M2 action but I'm not aware of muscarinic involvement when it comes to cannabis or benzodiazepines to any significant extent so I'm well and truly stumped but if I can solve this equation, I may be able to finally solve the anxiety and panic attacks.