MrBadExample
Greenlighter
- Joined
- Jan 9, 2018
- Messages
- 8
Hi,
I've been doing a bit of research into oral administration of heroin;
The pharmacokinetic data suggest that it should work at least as well as oral morphine, however no one seems to have tried it so I am wondering why.
The reason this interests me is simple, I enjoy taking opiates, at most once per week, but I want to avoid any ROA that causes the drug to get into the bloodstream too rapidly, as this makes addiction more likely.
Taking opiates orally (poppy tea, morphine, codeine, etc), I have never felt any withdrawal or anything more than a slight desire to use more often than I should.
The first proper opiate experience I had was with oral morphine solution (Oramorph in the UK).
I took a small dose (10 - 15mg of morphine) and I was very high for almost a whole day (I took it at 2pm and my pupils were still myopic (?) the next morning).
I'm not sure why it lasted so long, maybe my liver is missing (this would also explain why codeine isn't very impressive :D ).
However morphine is not cheap because it is usually diverted from prescription medicine I suppose (there doesn't seem to be an illicit trade for morphine because heroin is more profitable), and poppy tea isn't quite as good in my opinion (it is close, but it seems to be less euphoric, and the body load seems to be stronger)
So this is why I am considering buying heroin and taking it orally.
According to Wikipedia, morphine has an oral bioavailability of 20?40%.
And for heroin:
"Heroin's oral bioavailability is both dose-dependent (as is morphine's) and significantly higher than oral use of morphine itself, reaching up to 64.2% for high doses and 45.6% for low doses; opiate-naive users showed far less absorption of the drug at low doses, having bioavailabilities of only up to 22.9%."
So the oral bioavailability seems to be roughly the same for both.
Now, heroin is up to 4 times as potent as morphine, so even if the heroin I buy is only 25% pure (seems a bit low), it will still equal the effect of morphine, and it is still cheaper, weight for weight.
I suspect the reason that there is very little information about this is that heroin tends to have a very bad reputation, consequently, it is seen as a "last resort". People usually switch to heroin because it is more cost effective. This means that they already have a heavy opiate habit, probably daily use. This means that their tolerance would be quite high, necessitating an ROA that gets the levels in the blood as high as possible, as quickly as possible.
Oral is the slowest ROA for heroin so this wouldn't be desirable.
That is just my theory, I mean no disrespect to anyone, I am simply stating what I believe to be true.
Also:
"clinical studies comparing the physiological and subjective effects of injected heroin and morphine in individuals formerly addicted to opioids; these subjects showed no preference for one drug over the other. Equipotent injected doses had comparable action courses, with no difference in subjects' self-rated feelings of euphoria, ambition, nervousness, relaxation, drowsiness, or sleepiness."
This suggests that heroin is simply a more potent version of morphine, and that its effects are much the same, therefore oral use of heroin wouldn't be any more addictive than oral morphine use.
So I am really looking for a long-lasting high with no rush and no harsh come down. This, I hypothesize, is the only hope I have in maintaining a regular opiate habit without addiction.
Does anyone know if there is a reason that oral heroin is no good, or should I give it a go?
Thanks in advance.
I've been doing a bit of research into oral administration of heroin;
The pharmacokinetic data suggest that it should work at least as well as oral morphine, however no one seems to have tried it so I am wondering why.
The reason this interests me is simple, I enjoy taking opiates, at most once per week, but I want to avoid any ROA that causes the drug to get into the bloodstream too rapidly, as this makes addiction more likely.
Taking opiates orally (poppy tea, morphine, codeine, etc), I have never felt any withdrawal or anything more than a slight desire to use more often than I should.
The first proper opiate experience I had was with oral morphine solution (Oramorph in the UK).
I took a small dose (10 - 15mg of morphine) and I was very high for almost a whole day (I took it at 2pm and my pupils were still myopic (?) the next morning).
I'm not sure why it lasted so long, maybe my liver is missing (this would also explain why codeine isn't very impressive :D ).
However morphine is not cheap because it is usually diverted from prescription medicine I suppose (there doesn't seem to be an illicit trade for morphine because heroin is more profitable), and poppy tea isn't quite as good in my opinion (it is close, but it seems to be less euphoric, and the body load seems to be stronger)
So this is why I am considering buying heroin and taking it orally.
According to Wikipedia, morphine has an oral bioavailability of 20?40%.
And for heroin:
"Heroin's oral bioavailability is both dose-dependent (as is morphine's) and significantly higher than oral use of morphine itself, reaching up to 64.2% for high doses and 45.6% for low doses; opiate-naive users showed far less absorption of the drug at low doses, having bioavailabilities of only up to 22.9%."
So the oral bioavailability seems to be roughly the same for both.
Now, heroin is up to 4 times as potent as morphine, so even if the heroin I buy is only 25% pure (seems a bit low), it will still equal the effect of morphine, and it is still cheaper, weight for weight.
I suspect the reason that there is very little information about this is that heroin tends to have a very bad reputation, consequently, it is seen as a "last resort". People usually switch to heroin because it is more cost effective. This means that they already have a heavy opiate habit, probably daily use. This means that their tolerance would be quite high, necessitating an ROA that gets the levels in the blood as high as possible, as quickly as possible.
Oral is the slowest ROA for heroin so this wouldn't be desirable.
That is just my theory, I mean no disrespect to anyone, I am simply stating what I believe to be true.
Also:
"clinical studies comparing the physiological and subjective effects of injected heroin and morphine in individuals formerly addicted to opioids; these subjects showed no preference for one drug over the other. Equipotent injected doses had comparable action courses, with no difference in subjects' self-rated feelings of euphoria, ambition, nervousness, relaxation, drowsiness, or sleepiness."
This suggests that heroin is simply a more potent version of morphine, and that its effects are much the same, therefore oral use of heroin wouldn't be any more addictive than oral morphine use.
So I am really looking for a long-lasting high with no rush and no harsh come down. This, I hypothesize, is the only hope I have in maintaining a regular opiate habit without addiction.
Does anyone know if there is a reason that oral heroin is no good, or should I give it a go?
Thanks in advance.
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