opioid alternative, from a fungi!?

[asecin]

i was checking this; https://www.medicalnewstoday.com/articles/326715.php and as usual im pissed off at how poor those science articles can be. its not giving you anything to go on! it just says oh yeah this fungi we found, it has SOME "tetrapeptide" that can be alternative to opioids and.... end of article. nice eh?
anyway, im posting this here so people with more knowledge help me out a bit. do you guys have more information on this tetrapeptide? from what i gathered, there are some really reliable for medicine tetrapeptides already available, just checking wiki; https://en.wikipedia.org/wiki/Tetrapeptide so it must be something good. i have to learn more tho, and i wish people on this section on the forum have more information to add to this!

 

[sekio]

"tetrapeptide" just means a protien made of 4 amino acids

PNAS article: https://www.pnas.org/content/early/2019/10/08/1908662116
structure: (3c, bilorphin is the opioid-active compound)

unfortunately peptide opioid receptor drugs tend to be very "poorly behaved" i.e. they are degraded to individual amino acids if eaten, they are too large to penetrate BBB effectively, and have relatively short half lives. this is why you don't see people using IV endorphin to kill pain or as a euphoriant, it must be administered ICV (into cerebroventricular space, injected into the brain/spinal fluid)

other peptide opioid agonists are known eg. DAMGO, DADLE, endorphin, enkephalin etc.

 

[AlphaMethylPhenyl]

^Must be pretty big, as exogenous psychoactive opioids are peptides (all of them, really). Lipophilic potential must also factor into this, but I don't know how. I'm mostly in biology.

 

[asecin]

"tetrapeptide" just means a protien made of 4 amino acids

PNAS article: https://www.pnas.org/content/early/2019/10/08/1908662116
structure: (3c, bilorphin is the opioid-active compound)

unfortunately peptide opioid receptor drugs tend to be very "poorly behaved" i.e. they are degraded to individual amino acids if eaten, they are too large to penetrate BBB effectively, and have relatively short half lives. this is why you don't see people using IV endorphin to kill pain or as a euphoriant, it must be administered ICV (into cerebroventricular space, injected into the brain/spinal fluid)

other peptide opioid agonists are known eg. DAMGO, DADLE, endorphin, enkephalin etc.

i was checking other tetrapeptides which are already used ,as the wiki url posted, and do have medicinal value. so it must have some reliability in the future use if perhaps maybe altered a bit? in your opinion there is no potential to be had with this new tetrapeptide at all? the scientists involved with finding it seem very enthusiastic about it, and im sure they know better if this will have any use or not