Opiate Enzyme Deficiency Questions...

[ShaunG]

If you had a CYP450 or another enzyme deficiency, is there anything you could do to help opiates absorb and metabolize better? Lets say you are partially deficient, will inhibiting CYP450 help at all?

Also, can you develop this deficiency, or is it strictly genetic?

What deficiency would be for oxycodone?

Any information would be appreciated.

 

[ShaunG]

Is there a better forum for this post?

 

[Non Nobis Solum]

MOVED FROM OD TO NPD! Anyone able to help this man out?

 

[endotropic]

If you had a CYP450 or another enzyme deficiency, is there anything you could do to help opiates absorb and metabolize better? Lets say you are partially deficient, will inhibiting CYP450 help at all?

Also, can you develop this deficiency, or is it strictly genetic?

What deficiency would be for oxycodone?

Any information would be appreciated.

First of all CYP450 are a large set of different metabolic enzymes in your liver. That means no matter what CYP450 genetics you have the drug will get absorbed just as well, since the liver doesn't control drug absorption.

Also if you cause a drug to get metabolized better (in most cases) that means the drug breaks down faster and has more limited effects. Codeine is one exception because CYP2D6 metabolizes it into morphine, so codeine is a rare case where increasing CYP450 metabolism can lead to increased effects.

There are genetic, dietary, and drug effects on the CYP450 enzymes. So you can develop a deficiency in the sense that another drug you're taking could limit CYP activity, but if you stop taking the drug you'll return to your normal genetically determined activity. Most effects on CYP enzymes (drug, dietary and genetic) inhibit their activity; it's a bit more rare to find an effect that increases their activity.


Long story short if your oxycodone isn't working as well as you'd expect it's probably not a problem with your CYP activity.

 

[Black]

If you had a CYP450 or another enzyme deficiency, is there anything you could do to help opiates absorb and metabolize better? Lets say you are partially deficient, will inhibiting CYP450 help at all?

Also, can you develop this deficiency, or is it strictly genetic?

What deficiency would be for oxycodone?

why would you want to metabolise opioids (except codeine, dihydrocodeine and tramadol) quicker? your high would be shorter.
if you are partially deficient, inhibiting the respective CYP450 enzyme would (obviously) exacerbate the deficiency.

it's strictly genetic if you don't account for xenobiotics that temporarily alter CYP450 activity like for instance grapefruit juice (or some pharmaceuticals).

oxycodone is metabolised by a few different enzymes into quite a few different products, some of which are active - and this is where it would get complicated. but oxycodone is the main psychoactive compound, so extensive metabolisers typically get less effects while slow metabolisers get stronger effects.