sarbanes
Bluelighter
- Joined
- Mar 8, 2007
- Messages
- 481
many mis-understand why exactely loperamide is (generally) non-centrally active. yeh, one day loperamide will be banned...best to just not talk about it, but you can't control what peps say. i truly believe malfunction meant well, and truly believe him, but its best this sort of thing just isin't talked about. we might not see it banned soon because to do so would implicate FDA was wrong all along. then again, if it becomes major problem...u never know. loperamide most certainly is a peripheral mU opioid agonist, & competition w/ p glyco protein (efflux), synergistic with blood/brain considerations, limit its central potential. weaken either one of these, and loperamide can be centrerally active. those who smoke (or find ways to instantly take large doses), even if under 100mg, can get a high as long as the dosage is acute enough to temporarily overcome p-glycoprotein competition. therefore, have heard of peeps smoking 20mg loperamide and nodding hard.