^^ I wasn't specifying for any specific ROA I was answering his question as to why people would be suggesting the use of a high fat meal.
I never stated what route I was referring to though I do realize his post is in regards to nasal admin.
However his question regarding why people where mentioning a high fat meal did not seem route specific.
Though as for "how the hell" something in your stomach would change absorption from your nasal cavity I'd have to look for specifics.
Regardless I'll venture a guess.
From the best of my understanding it would have to do with fact that Oxymorphone is lipid-soluble.
Increasing the lipid-content of the blood would mean that there is more lipids for the Oxymorphone to "bind" to and help with BBB penetration.
This would explain the increase in perceived strength, although I'd have to look for some more information to confirm this hypothesis.
Again this is just a guess that is way over simplified but perhaps someone more knowledgeable could chime in.
If I'm wrong on the mechanism I apologize but from personal experience it does seem to also affect nasal usage.
It could always be placebo but I'd be more inclined to believe something along the lines of my prior hypothesis.
Or perhaps something similar involving lipids but through a different mechanism of action.
No matter how you look at it your welcome to your have your own opinion on the matter.
Even if my hypothesis &/or mechanisms of action are wrong regarding this the following would still be relevant.
That being the case I hope you don't entirely dismiss the idea of eating something being able to affect nasal admin of various substances.
By doing so you would be discounting enzyme inhibition through oral admin of enzyme affecting foods; for example Grapefruit.
I doubt anyone could totally discount the effect of a enzyme inhibitor taken orally on the effect of a nasally administered Opiate
that is metabolized by the corresponding enzyme which your blanket statement would imply.
I'm not positive offhand as to what enzymes would effect Oxymorphone but for more information you could check out
Pharmacokinetic Drug Interactions of Morphine, Codeine, and Their Derivatives: Theory and Clinical Reality.
Also if anyone happens to be interested in the affect of a high fat meal on oral admin check out this link
Sustained release formulations of oxymorphone
Anyways, I'm getting off-topic & I apologize to others in the thread for my TLDR response to Oppyandme.
I just wanted to reply to Oppyandme's statement as the eye-rolling at my attempt to help answer the OP's question seemed unnecessary.
Regardless no ill will intended & I hope that my response helps to clarify any misconceptions.