Tehuti
Bluelighter
- Joined
- Jun 18, 2007
- Messages
- 31
Hello all
swim has footed about for a while now but decide to join after reading a post about O-Desmethyltramadol. Swim sees some great minds in this bit of the forum, so thinks it will be a good place to talk. swim understand this has been talked about before but was wondering if we can advance on it.
How do you think (+)-O-Desmethyltramadol could be made better and do you think the synth from Tramadol to (+)-O-Desmethyltramadol or other close relatives of it is doable by a pro?
swim have read what harobo1 seid “acetylation of the phenol would allow the drug to jump through the BBB” who agrees this will work in the same way as Morph to H?
What about other analogues of tramadol that are more opiate selective
This is what happened to some rats after getting some (+)-O-Desmethyltramadol notice how 5mg/kg led to sever respiratory depression but it was not until 30mg/kg that one of the rats died, is this normal in opiate use a long dose response curve? also is muscle rigidity normal?
5¿mg¿kg-1 led to severe respiratory depression, so that only two rats were tested with this dose. One of these rats exhibited myoclonic twitches before ADT determination (Table 1). ADT was not affected (not illustrated). At 10 and 30¿mg¿kg-1 (tested in two rats each), severe respiratory depression and catalepsy with muscle rigidity, but no seizures were observed. ADT was not affected at 10, but markedly increased at 30¿mg¿kg-1 (not illustrated). One of the rats treated with 30¿mg¿kg-1 died within 24¿h after drug injection. In nonkindled rats, severe respiratory depression was observed following 10 or 30¿mg¿kg-1 of the metabolite
Could this long dose response (if it is) curve be because of Stimulation of μ1-receptors more than (or only) and little (or not) of μ2?
Which one is responsible for the high μ1?
swim likes talking about opiate analogues there are so many of them also pharmacolagy
Many thanks
swim has footed about for a while now but decide to join after reading a post about O-Desmethyltramadol. Swim sees some great minds in this bit of the forum, so thinks it will be a good place to talk. swim understand this has been talked about before but was wondering if we can advance on it.
How do you think (+)-O-Desmethyltramadol could be made better and do you think the synth from Tramadol to (+)-O-Desmethyltramadol or other close relatives of it is doable by a pro?
swim have read what harobo1 seid “acetylation of the phenol would allow the drug to jump through the BBB” who agrees this will work in the same way as Morph to H?
What about other analogues of tramadol that are more opiate selective
This is what happened to some rats after getting some (+)-O-Desmethyltramadol notice how 5mg/kg led to sever respiratory depression but it was not until 30mg/kg that one of the rats died, is this normal in opiate use a long dose response curve? also is muscle rigidity normal?
5¿mg¿kg-1 led to severe respiratory depression, so that only two rats were tested with this dose. One of these rats exhibited myoclonic twitches before ADT determination (Table 1). ADT was not affected (not illustrated). At 10 and 30¿mg¿kg-1 (tested in two rats each), severe respiratory depression and catalepsy with muscle rigidity, but no seizures were observed. ADT was not affected at 10, but markedly increased at 30¿mg¿kg-1 (not illustrated). One of the rats treated with 30¿mg¿kg-1 died within 24¿h after drug injection. In nonkindled rats, severe respiratory depression was observed following 10 or 30¿mg¿kg-1 of the metabolite
Could this long dose response (if it is) curve be because of Stimulation of μ1-receptors more than (or only) and little (or not) of μ2?
Which one is responsible for the high μ1?
swim likes talking about opiate analogues there are so many of them also pharmacolagy
Many thanks
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