Misc Nutmeg + Chlorpromazine

[thrash89]

I was just wondering if there was an interaction between chlorpromazine and nutmeg, I dosed 3 tablespoons and I need to take some chlorpromazine.

Thanks

 

[Hodor]

As far as I know, nutmeg (at recreational doses) has anticholinergic effects, and so do old-timey phenothiazine antihistamines/antipsychotics like chlorpromazine, so the increased anticholinergic effects might actually offset chlorpromazine's sedating effects, and make the nutmeg trip even more unpleasant.

 

[Etterwonde]

Why would you use nutmeg? I've heard it gives a very shitty high as a deliriant...

 

[kleinerkiffer]

As far as I know, nutmeg (at recreational doses) has anticholinergic effects, and so do old-timey phenothiazine antihistamines/antipsychotics like chlorpromazine, so the increased anticholinergic effects might actually offset chlorpromazine's sedating effects, and make the nutmeg trip even more unpleasant.

Exactly

Toxic symptoms are dose-related and primarily anticholinergic, including dry mouth, GI upset, flushing, palpitations, agitation, blurred vision, miosis, hypotension, hypothermia, hallucinations, as well as coma and death.

https://www.aacc.org/community/divisions/tdm-and-toxicology/toxin-library/nutmeg

Additionally nutmeg seems to be a MAOI

Myristicin has a weak monoamine oxidase inhibitor action

https://emj.bmj.com/content/22/3/223

 

[Speed King]

You kiddies need to think about the repracussions. If you are only taking a little nutmeg it will suck less, but be prepared to drink plenty of water. This should make you really thirsty.