So I should start off with saying the title is not 100% true, I smoke weed almost daily and I get effects from it just fine. On the other hand, any other drug i've taken in the last couple of months has done nothing. I'll snort oxy and wait and wait for effects, but I never get a nod or any euphoria and sometimes I just get irritated. Im prescribed a ssri for depression and I dont take it, ive heard ssri's can reduce effects of opiates but I havent felt effects on or off of them. I will take upwards of 8 grams of kratom and feel nothing, I took a handful and a half of my anxiety medication, which made me feel sort of sedated and good feeling the first time I did it, but lately im just not getting effects. I have extreme depression and I dont know if it is a factor. I dont think it is a tolerance problem because it happens with several drugs and I only do them about once a month. Has anything similar happened to anyone else?