M Brace - nice name btw - I have used memantine and MDMA and if anything, the MDMA knocked out the memantine's hold on my lungs. Being a stimulant that shouldn't be surprising. The issue I had with memantine is I noticed marked respiratory depression once I hit the recommended 40mg marker. I did, however, test out MDMA on memantine and I noticed that I could breathe again. Well store-bought ephedrine did the same thing back when it was easy to get (ah, the primatene days).
Anyway, DXM ***HBr*** is *NOT* the form you need for long term NMDA antagonism. DXM itself is not what is needed - we want the DXO. DXO is a semi-potent NMDA antagonist but it has a short half life. When you "get fucked up" on DXM, you use the HBr version which as soon as it hits the liver it is rapidly metabolized by CYP2D6 to DXO which is then processed by the body and we have a DXM trip. If I remember correctly, DXM by itself is pretty much a SRI (serotonin reuptake inhibitor) which is why certain people low in CYP2D6 liver enzymes have extremely long trips and sometimes dangerous reactions to high dose DXM. This is also the reason that DXM, unlike the traditional NMDA antagonists like ketamine, PCP, methoxetamine, alcohol (yes its an NMDA antagonist among other things), etc - in low doses it feels quite serotonergic. Nice and fluffy. I don't know any dose of K that makes you feel like you're on a mild to moderate roll. DXM is active on its own and its activity on serotonin is much more responsible for the serotonin syndrome fear when combined with MDMA or other serotonin releasers than DXO is.
Anyway, that was really scattered... DXM ***POLISTEREX*** is what you need. The conversion factor between HBr and Polisterex is entirely different. Polisterex (ONLY available as Delsym, no generic form) is an edible plastic... its like an enteric-coated DXM molecule... the stomach slowly eats away at the plastic and sends the DXM down for absorption (and subsequent conversion) to DXO over the course of 8-12 hours (depends on metabolism like all things). This is where the magic comes in. NMDA *stays* antagonized and gives the brain a chance to recover at GABA (and probably dopamine receptors).
Now as far as MDMA goes - seriously dude, once you've lost the magic, you've lost the magic. Piracetam has been shown to bring it back but it also increases the potency of MDMA and while in my experience it lessened cardiac effects of MDMA, I have heard the opposite as well.
Now referring to DXM's ability to ameliorate anxiety, this is because N-Methyl-D-aspartate (NMDA) is the "excited" part of the brain. It is what makes us react to certain situations and has been shown to trigger adrenaline release. When you have sufficiently beaten down NMDA you have done two things - one, eliminated most of the brain's causes of anxiety (AMPA plays a role in anxiety as well but the only well-known AMPA inhibitor I know of is Topamax. In my circle we call it Dope-a-max, or Stupidmax because it dulls you down THAT much) and two increased the brain's "calming" side - gamma-aminobutyric acid (GABA). The balance of these two is something the brain always tries to achieve. When you consume too much glutamate or alcohol/benzos you can alter that balance drastically.
Basically all this method seeks to do is allow the brain to compensate for the loss of NMDA (due to inhibition) by producing more GABA. The flipside of the coin would result in seizures and death. If you antagonize GABA, the brain flips on the NMDA switch and we seize and eventually die from cell overactivity.
This is pretty much a crude way of tricking the brain into thinking it needs to produce more GABA.
EDIT: Shit, I forgot to add... I just started Delsym for Klonopin taper... First night... 16-17mL... I have had a few beers and one thing I always noticed with beer was my heart rate. Plagued me even when falling asleep. Now I know that taking trazodone with DXM can cause permanent liver damage so its either Remeron (which has an extremely sketchy pharmacological profile IMO) or just go to sleep on my own... well I walked to the bathroom because Delsym has an annoying "flush" effect on my bowel system the first few days... checked my pulse... normally would be about 120 or so with alcohol... yet it was around 70-80... that's my normal resting (smoker) - its obviously already doing its job... I feel pretty relaxed although my body is quite angry with me... my CNS is quite calm. Its the southern region that wants to punch me in the face. I think that the antagonism starts pretty fast... That's not to say I'm going to skip my Klonopin tomorrow... I might wait 6 hours or so but take my Delsym as normal... I'll report back on what I decide to do and see what happens. I know that normally missing it more than an hour usually puts me in rebound mode but 20mL might just do the trick.
