So looking around the web, one can find a great deal of anecdotal reports and testimonies and even a few studies that low dose naltrexone can help sufferers with all sorts of conditions associated with chronic pain, and that ultra low dose naltrexone can slow tolerance to opiates, etc... and that these effects are likely the result of opioid receptor antagonism causing upregulation.
It is also theorized that other kinds of antagonists, e.g. dopamine antagonists, when taken long term in high doses are thought to induce changes that lead to tardive dyskinesia, as a result of dopamine hypersensitivity.
Now you might have already guessed, but my question is this: Is there a possibility that high dose, long term naltrexone could lead to a condition where one becomes hypersensitive to endogenous opioids?
Note: I am not an opiate user. The only high I want to enhance is my body's "natural" one
It is also theorized that other kinds of antagonists, e.g. dopamine antagonists, when taken long term in high doses are thought to induce changes that lead to tardive dyskinesia, as a result of dopamine hypersensitivity.
Now you might have already guessed, but my question is this: Is there a possibility that high dose, long term naltrexone could lead to a condition where one becomes hypersensitive to endogenous opioids?
Note: I am not an opiate user. The only high I want to enhance is my body's "natural" one