Naloxone

[SchapMd]

I've been on subs for awhile now and I was wondering if naloxone is absorbed the same way bupe is. Which is through the vascular system. Or is it processed In the gut?

 

[PotatoMan]

homeless ---> BDD

 

[Raysu]

Naloxone is metabolized primarily hepatically (by the liver) but it's pharmacokinetics are not fully understood yet either.

 

[DrJay]

Naloxone has limited oral/ GI/ trans-buccal (cheek) bio-availability, which is puzzling as it is absorbed intra-nasally.

 

[SchapMd]

Thanks for your input. Curious stuff that naloxone is.

 

[SS373dOH]

Wanted to add about the intranasal bioavailability.. the website that I seen that had its b.a. around 24%-30%, had another contradicting page, and had it listed at 4%.. http://www.ncbi.nlm.nih.gov/pubmed/18641540 < The "4%" page..


- Hopeless

 

[SchapMd]

Does anyone have any ideas on how to diminish the effects of the naloxone in a 8 mg strip of suboxone. The doc won't switch me to straight bupe which is unfortunate.
Thanks.

 

[pally pete]

I'll never forget being Narcaned! (Narcan - Naloxone) when I took 800mg Oxycontin.

One of the worse experiences of my life! Itfelt like arctic cold air was being pumped through my vains. Then I felt the intense back pain to which I was told was Kidney failure. Scary experience.

 

[SchapMd]

That's what happened to me when I took a sub after being on methadone for years. I was told 24 hrs and I'd be OK . nope . blew my mind. That's why I'm looking to find a way to kill the naloxone in these things. I'm worried I'll never get high again.-saturated