It would increase the activation of naloxone, but when dealing with a substance with a 6% oral bio avail. It makes sense to me that most likely that would increase when insufflated.
Tilidine is and agonist but when you add naloxone into the tablet an pure antagonist you have a partial/mixed agonist/antagonist. It might not be a partial agonist in the true definition of the word but it is definetly a mixed agonist/antagonist. Tilidine is an agonist when in pure form such as with Valoron drops/caps
link.
I was speaking on its strength compared to other opiates. In a double blind study tramadol drops were picked as a better 'analgesic' over Tilidine drops [w/ out the Naloxone]. It is commonly used for stage 2 pain [tramadol, hydrocodone, etc]. I suppose inferior was not the best choice in words. I was not underestimating it, I was actually encouraging the OP to give it a try as it looks like it has potential. It seemed people were telling him not to try it. It seems perfectly safe to me in 1-2 tablets oral or 50mg snorted and was affirmed with this old post:
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Different drug, similar properties. Naltrexone pills/implants are usually given to opiate addicts that have been clean for awhile so that if they do use there use will be blocked and it is worthless attempt. Its so easy not to take a pill so thats when they came out with the Naltrexone implant so you cant skip a dose and get high.
Untrue, with Naltrexone a long lasting orally active antagonist you will have trouble getting high off anything. With Naloxone [a whole different story] you can get high off other opiates as it is so short acting. See my post above concerning methadone patient being administered Narcan/Naloxone, the naloxone will wear off and the high from methadone will still be present. Thats why its common in methadone OD's for the patient to have multiple infusions of naloxone in order to clear out the receptors completely. Also according to the Buprenophine Bible 'Treatment Improvement Protocol (TIP) Series 40' that Buprenorphine binds to the mu receptors so strongly that it is not dislodged even by Naloxone injections. OD'ing on bupe while extremely hard is also extremly hard to reverse because of buprenorphines high affinity to the opiate receptor sites.
Also, a substantial percentage of individuals currently abusing heroin or other opiates do not show any evidence of withdrawal when challenged with naloxone. Between 34 and 61 percent of patients applying for methadone maintenance may have minimal or no response to intravenous or intramuscular naloxone in doses ranging from 0.2-1.2 mg.
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So yes it is possible to get high [off other drugs ] with Naloxone. In my personal experience one time I OD'd got a shot of naloxone and was shooting heroin again but 1-2 hrs later and getting high. While this might be a play on semantics it is possible disregarding Naltrexone, even though I have had friends that have shot dope on Naltrexone and gotten sick and continued shooting dope and broke thru past the blocking effects and gotten the sickness to subdue and a mellow buzz to occur, dangerous extemely. Would I try that? Fuck no.
Blase:
Have you tried the pills yet? I am curious as to what you get off 1-2 pills orally or 50mg tilidine/4mg Naloxone insufflated.