N-benzyl phens may not be as selective as we once believed.

[ebola?]

Yeah, he's pretty fucking old and male, so it's hard to tell.

ebola

 

[nuke]

It looks like DOI-nBOMe might be a winner: its binding affinity is a great deal weaker than 25i-nBOMe's, but maybe that means that it'll be active at levels people can actually measure. Its partial agonism should improve safety.

ebola

I'm more interested in the 24NBOH series... Notice the Ki is extremely low but the EC50 is very high. While it's true that the intrinsic activity is about as high as the 25NBOMe compound, you probably need a huge dose to get there.

EC50 / Ki
24NBOH 110.4
25NBOMe 28.7
25NBOH 52.8

I'm guessing IM/IP/IV these compounds are about as safe as DOI, the problem is the variable absorbance sublingually or nasally

 

[N0 W4RN1NG]

This doesn't worry me in the slightest...how often are you guys tripping? For me it's just a few times a year. Don't forget LSD itself is a super potent 5HT2B agonist, and it lasts longer!

EDIT: Sorry for necrobump :x

 

[Asante]

I decided against experimenting with benzylphenethylamines. Right from the start there were indications that they triggered a grapeshot of receptors and there were plenty of reports of trips becoming physically problematic.