HOOH
Bluelighter
- Joined
- Apr 21, 2021
- Messages
- 421
There doesn't appear to be any data concerning applied 4-AcO-DMT on neuron cultures, merely the HTR of rodents when they are administered 4-AcO-DMT, which is ofcourse not surprising, since 4-AcO-DMT gets converted to 4-HO-DMT.This is a lie. The acetoxy group is not too large for the molecule to have an effect. https://bitnest.netfirms.com/external/10.1016/j.neuropharm.2018.02.028 This study found that 4-AcO-DALT has similar affinities to DALT and 4-HO-DALT. It's reasonable to assume that 4-AcO-DMT has affinities similar to DMT and 4-HO-DMT.
The reason why 4-AcO-DMT is unable to bind in of itself, is because the acetoxy group prevents the straight 45 degree angle that the ethylamine chain needs to have to be able to bind to the receptor, furthermore, there is hydrogen bonds present between the moieties that further destabilizes that specific conformation. This is also related to the low-affinity that 4-MeO-DMT has.
And even if 4-AcO-DMT would have activity, that doesn't exclude the fact that the Acetoxy group gets cleaved off very rapidly in the body, before sufficient binding could even occur