So when I'm on a drug binge I take Tramadol, Chlorpheniramine and Fluoxetine (prescribed SSRI) - I am aware these three drugs have an effect on serotonin, and I would be at risk of serotonin syndrome, but lately I keep seeing that Morphine also has serotonin altering properties? I haven't heard of this. I just thought it was only Tramadol that can cause issues when mixed with SSRI's. So what do you guys think?
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BDD Moderators: Keif’ Richards | negrogesic
Morphine causing serotonin syndrome?
- Thread starter Novocaine
- Start date
fermonos
Bluelighter
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- Sep 29, 2016
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If you're taking Tramadol and Fluoxetine at the stated dosage by your Doctor. You should be fine, but if you're abusing Tramadol and taking 200mg+ in one go then SS is a risk. Even taking Tramadol alone at the stated dose can give you SS.
So mixing SSRI's with Tramadol which effect the Serotonin levels in your brain can obviously cause negative effects.
So mixing SSRI's with Tramadol which effect the Serotonin levels in your brain can obviously cause negative effects.
Pilll_head
Bluelighter
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- Sep 28, 2011
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- 466
Tramadol is known to be a serotonin reuptake inhibitor, so combining this with SSRIs will lead to too much serotonin and SS. As far as the morphine and its close cousins like hydro and oxy, I took those for years while on high doses of an SSRI and Remeron (a serotonin replacement drug) and never noticed any serotonin syndrome.