So when I'm on a drug binge I take Tramadol, Chlorpheniramine and Fluoxetine (prescribed SSRI) - I am aware these three drugs have an effect on serotonin, and I would be at risk of serotonin syndrome, but lately I keep seeing that Morphine also has serotonin altering properties? I haven't heard of this. I just thought it was only Tramadol that can cause issues when mixed with SSRI's. So what do you guys think?