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  • BDD Moderators: Keif’ Richards | negrogesic

Modafinil / Modalert - combination with Tramadol?

C

chris106

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Joined
Jan 16, 2013
Messages
48
Hey everyone!

I just recently started taking Modalert (Modafinil Generic) against my ADD-Symptoms and daytime-sleepiness.

However, I've also been experimenting with Tramadol against a certain problem before... Sadly I suffer from a quite severe case of PE (if you don't know what that means, Id rather if you don't ask >_<)
It may be news to some, that Tramadol actually helps with this condition - I got the advice from a german "men's health"-related forum, where some people with PE had remarkable results with it. (some however didn't, and doses vary)

I've allready tried up to 200mg Tramadol, and despite some stomach-issues it actually does work against the PE - when taken alone.
I also tried taking it while on amphetmamines. But since they stimulate the ZNS it didn't work in that case.

Now my question is - is it safe to try Tramadol while under Modalert?
I take 200mg modalert in the morning and sometimes another 100mg in the afternoon. Of course I would start with low doses of 50mg Tramadol and work my way up from test to test... allways leaving pauses of a few days in between.

Since Modafinil works differently than amphetamines, I'd hope that Tramadol could still work - or would they just cancel each other out, or even produce dangerous effects?

I'd be really thankfull for any advice!
 
I've seen some studies to indicate that Modafinil possesses some dose dependent anti-epileptic properties. Other excerpts I have read mention that Modafinil has a minimal effect on the seizure threshold. I still wouldn't risk it it though as it's still considered a sympathomimetic stimulant and they tend to aggressively lower the seizure threshold much like tramadol.
 
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I would really avoid amphetamine and tramadol together! Amphetamine increases levels of norepinephrin and tramadol inhibits reuptake of it, so you run a risk of dangerously elevated levels. Maybe serotonin syndrome isn't the biggest thing to worry about but you could easily get seizures on them.

The mechanism of action for modafinil doesn't seem to be well understood. Orexins seem to be involved but monoamine levels are IIRC also elevated if only from secondary effect. This, again, is no good with tramadol and the risks would be difficult to predict, calculate or understand.

Complications would be quite bad to begin, let alone when you're busy doing.. well.. other things.
When you are moving a lot / exercizing, heating up, etc, there is that much more chance of getting hypertension.

Better just avoid combining tramadol in a lot of cases, it doesn't really play well with other drugs. I'd say it is not worth exploring such avenues of combo's hoping for success if you could also investigate alternatives that have less risk. I can't suggest any off the top of my head but that is why I say: investigate or research.
 
kace said:
My worry is that it will increase the chance of seizures.

So far my experiments mixing them (but also with diazepam) have been fine.. just makes me feel slightly nauseous. I wouldn't take or mix them both on a regular basis though..
Click to expand...

Thanx for the information! I sure as hell wasn't going to do that on a regular basis. Not even the Tramadol alone. However, since I have no history of seizures whatsoever, I guess I'll very carefully give it a try, starting at low doses. But first I'll do a little more research, I guess.

And thanks to all the others who contributed to this thread, I now have enough Information to do more reseacrh and realistically calculate the risk! You guys are awesome! :3

EDIT:
@kaze: If I may ask - do you have history with seizures, or did you just add the diazepam to the mix to be extra-carefull in regard to preventing seizures? I ask because, like I said, plan on carefully trying the combination, but without diazepam, so I guess this could make an important difference...



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Well, I did the test yesterday. Took 50mg Tramadol (note: original pharma brand, no generic!) at 6:30 pm, and 50mg Modalert.
Didn't notive much of anything for about two hours. Then, at 9pm another 50mg of each. I then soon felt a little, well... jittery would be a too harsh word. More like when having smoked too much.. definetely nothing seizure-like. Even though I felt a tiny short muscular reaction every now and then. So nothing that had me really worried.

However, at 10:30 pm I felt like the sedation from the Trama kind of overlapped the good, "awake" feeling of the Moda, so I took another 50mg Moda ( probably could have just let that short phase pass without re-dosing the moda, though)

Then, at 11pm I added a "Levitra" to the mix, so my "friend" wouldn't be too "chilled"... plus 7mg "Omneprazol" for my stomach, since the Levitra tends to upset it a little.

Then at 11:45pm I did a little "self-testing" (it's funny how I feel like a total pervert when writing something like this in a forum that is NOT specifically men's health related ^_^' - please bare with me guys, it's in the name of science! :p)
And what do you know - I had amazing results regarding my annoying "problem".

I slept well that night, but had quite a headache this morning after waking up. However, 2 Aspirin fixed this quite nicely.

All that being said, I would definetely never go as far as to suggest others to try this combination. And if I should repeat it in the near future, I definetely wouldn't add anything like alcohol or nicotin to that mix. Also I won't do it regularly, of course.
But I guess when you suffer from such an annoying condition like me, you become willing to take a few risks and at least try something out.
To me it was amazing, how my long-time problem was suddenly non-existant for a short period of time.


Still, @ Kaze: If you read this, it would be really cool if you could answer my question in the post above. Still highly interested in reducing the risks, of course ;)
 
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Hi .
I had the same dilemma before and i really feel u should take the time and try PC muscle exercises and jelqing . It will really get u in control .
 
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