N&PD Moderators: Skorpio | thegreenhand
what are you trying to accomplish with this combo?
Anti-depressants focusing on serotonergic transmission tend to take 6-8 weeks to manifest efficacy. I think that this rapid-fire tinkering will prove counter-productive.
ebola
Back when MAOIs were in common use they would sometimes add amphetamine to help with sedation and hypotension. Possibly a TCA combo with desipramine or nortriptyline? I do not think combining mirtazapine with moclobemide would be an issue. At higher dosage its like an NRI with some serotonin receptor antagonism. Doesnt mess with SERT.
It isn't true that mirtazepine is free from the risk of serotonin syndrome. Although rare, cases have been reported in patients on mirtazepine who are not taking any other serotonergics:Um, no an amphetamine and an MAOI would CAUSE a preciptious hypertensive (quite possibly death) crisis and require hospitalization. and moclobemide and mirtazapine isn't dangerous. remeron doesn't cause serotonin syndrome with any serotonergic. It actually treats it. It blocks the excitatory 5-HT 2A receptors that release glutamate - the receptor responsible for the behavior syndrome.