I've only tried the traditional method with caapi and chacruna myself so I can't compare, but everyone I know who has tried the pharm method as well claim that there is a pretty big difference between the two and that the caapi will give you a much deeper and more significant experience but that the pharm method is still very powerful and no less meaningful.
I completely agree with Talker that if you chose to go with pharms, be aware of the dietary restrictions and risks associated with them, especially if you take any other medications.
I'm assuming you're already aware of this, but be ready for a hell or a ride... That's some powerful stuff you're dealing with here and it can completely change everything you though you knew about yourself. It's usually in a good way, but it can also go the other way.
For the "trip" itself, be ready for just about anything including thinking you're dying, as this is quite common in the first phase and can be fucking scary! Also, be ready to vomit like you never have before, and then vomit some more. I was honestly crying in pain and almost wishing to die just a few minutes into what ended up being a solid half hour of vomitting. It's worth the pain though and you forget about it within seconds when it really starts kicking in. Last but not least, if you have no one to watch over you during, remove everything you can from the space where you're taking it to make sure you don't hurt yourself or break anything because you could be moving involuntary and uncontrollably during the peak.
All that being said, keep an open mind, let it guide you and enjoy everything it brings you!