Hello bluelighters I was wondering if any of the more pharmacology knowledgeable users can share his/her opinion if metoclopramide could be negating some of ephedrine's effect.
I tried using the online Drug Interaction Checker website, which finds no interactions between the two, but once I took ephedrine and after half an hour, I felt not only the stimulating effects that I enjoy but also some nausea/feeling like vomiting so I took a metoclopramide tablet. And to my surprise 30 minutes later the effects of ephedrine almost dissapeared. Now I'm not saying that there is a causal relation between my taking mateclopramide with ephedrine, I could have been some other factor but still, that was the only time the effects of ephedrine diminished so drastically.
I know ephedrine is basically (indirectly) stimulating the adrenergic receptors, but I also read somewhere that the NA transporter system also carries a bit of dopamine with it (not sure if this makes any sense - but it was something like that), and metoclopramide appears to "bind to dopamine D2 receptors" as a receptor antagonist - according to wikipedia, and also works on 5-HT3 and 5-HT4.
So, if anybody is willing to share an opinion with me I would be glad, because ocasionally I feel a bit of nausea along with ephedrine and I would use it on theese ocasions but don't want to dumb down the recreational effects of ephedrine. (and yes, I am among the people who find ephedrine quite enjoyable recreationally though I know many people do not find anything interesting about it)
Thanks is advance.
(appologies if I misspelled some words or used unusual sentences - I did try my best but I don't have auto-correct and I am not from an english speaking country. This is also my first post on bluelight )
I tried using the online Drug Interaction Checker website, which finds no interactions between the two, but once I took ephedrine and after half an hour, I felt not only the stimulating effects that I enjoy but also some nausea/feeling like vomiting so I took a metoclopramide tablet. And to my surprise 30 minutes later the effects of ephedrine almost dissapeared. Now I'm not saying that there is a causal relation between my taking mateclopramide with ephedrine, I could have been some other factor but still, that was the only time the effects of ephedrine diminished so drastically.
I know ephedrine is basically (indirectly) stimulating the adrenergic receptors, but I also read somewhere that the NA transporter system also carries a bit of dopamine with it (not sure if this makes any sense - but it was something like that), and metoclopramide appears to "bind to dopamine D2 receptors" as a receptor antagonist - according to wikipedia, and also works on 5-HT3 and 5-HT4.
So, if anybody is willing to share an opinion with me I would be glad, because ocasionally I feel a bit of nausea along with ephedrine and I would use it on theese ocasions but don't want to dumb down the recreational effects of ephedrine. (and yes, I am among the people who find ephedrine quite enjoyable recreationally though I know many people do not find anything interesting about it)
Thanks is advance.
(appologies if I misspelled some words or used unusual sentences - I did try my best but I don't have auto-correct and I am not from an english speaking country. This is also my first post on bluelight )