Harm Reduction Metoclopramide + Amphetamines/Methylphenidate

[D-Amphety]

Metoclopramide is a medication used to treat nausea mainly but it works in an interesting way: it binds to dopamine receptors acting as an antagonist. Therefore stimulants theoretically appear to be potentiated.

I started experimenting with this recently and felt a slight increase in euphoria, but it could well be placebo. Would be interesting to see an actual study on this. Anyone ever heard of this interaction?

 

[Jabberwocky]

Metoclopramide will inhibit some of effect of amps by inhibiting them from agonisting dopamine 3 receptors so with enough dosage it will block hypersexuality , impulsivity, anti restless leg syndrome effect of amps/or any other dopamine releasing agent/ reuptake inhibitor

so it does the opposite

Are you saying it would block hyper sexuality of meth? That would be very useful I think.

 

[Jabberwocky]

Interesting. But I really don’t like mixing different drugs. I’m a purist. But I could be much more productive on meth if it was less pro-sexual.