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  • BDD Moderators: Keif’ Richards | negrogesic

Methylphenidate, Sildenafil and Sex - Interactions between Stimulants and PDE5 inhibitors

ritalin37

Greenlighter
Joined
Sep 19, 2021
Messages
1
Hi,

I have been using Methylphenidate for my ADHD; I take them sublingually for better bio-availability and it seems to give me a very euphoric high as well as the focus that I need. I also noticed that it increases libido and causes erectile dysfunction at the same time. I learnt that erectile dysfunction mainly happens due to vasoconstriction effects of stimulants; sometimes Methylphenidate also causes shortness of breath.

My dosage is 40 mg per day. (I have 20 mg pills; I try to not exceed two pills per day). In India it is marketed under the name Inspiral. It is instant release. Sometimes I exceed and take up to 60 mg. I usually split the pills into four or three different parts; then take each piece at different times of the day, after using a mouthwash that contains menthol. (I saw a paper that says menthol increases sublingual absorption).

I also found that PDE5 inhibitors like Sildenafil or Viagra causes vasodilation - the exact opposite of vasoconstriction. I have found small dosages like 15 mg of Viagra very useful in dealing with ed. But it also gives me very strong erection which makes sex feel more robotic and less pleasurable. Sildenafil also causes nasal congestion which worsens the shortness of breath if it is present.

While I am experimenting, I am wondering about one thing. Since vasodilation and vasoconstriction are opposite effects, do PDE5 inhibitors decrease the effectiveness of stimulants? Do they cancel out each other in anyway?
 
All the drug's that during my life i took, none really had an effect on my libido or erection.

Stimulant's and MDMA do indeed increase the 'lust'. Which at times can get a bit obsessive, can't imagine what would happen when after an orgasm your erection stay's. That is a side effect of Viagra right.

So what does decrease the pleasure of sex for me. Moodstabilizer'r a.k.a anti-Epileptic's, Valproic Acid and Levetiracetam both do this to me and i know no way around it.

l-Arginine maybe, https://pubmed.ncbi.nlm.nih.gov/12851125/
 
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