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  • BDD Moderators: Keif’ Richards | negrogesic

Methadone and Oxycontin together?

PMS

PMS

Bluelighter
Joined
Jan 3, 2012
Messages
145
Hello,

I'm on 40mg's of methadone syrup daily, taken at/with breakfast every morning.

Would it be "okay" to consume oxycontin together with the methadone, maybe not at the same time, but 4-8 hours after taking the methadone.

I ask because I once tried to take buprenorphine on top of my methadone, and got really sick.


I'm also unsure how much oxycontin would be OK to I.V., in my situation.
(Just to make sure I won't die, but still get really high).

Thank you! :)
 
I can't tell you how much Oxycontin you can shoot safely but I can tell you that you won't get sick like you did with Buprenorphine.

What you experienced with Buprenorphine is called precipitated withdrawal. Buprenorphine must never be taken when you are dependent on opiates/ opioids till you are withdrawaling pretty hard.
 
Okay. Thank you for your answer!

I guess I can't really trust anyones opinion regarding dosages. A better question might be, what is an average dose of oxycontin to shoot?

thanks.
 
No there would NOT be precipitated withdrawal! That only happens with Subutex or Suboxone.
I've done Oxy while on Methadone (also shot morphine, heroin and fentanyl on it) and it's totally fine.

I'd shoot like 20mg maybe. If it's not enough you can only use more, but if you use too much you can never undo it.
 
There is seriously no point in trying to shoot oxy. It does not have a rush when IV'd and the oral BA is already high. If you want it to be fast hitting, the intranasal BA is only slightly lower and the rest goes into your stomach with the drip anyway.

My preferred ROA for oxy is up my nose and orally - usually I halve my dose and do half and half, that way it hits quick up the nose then the oral dose keeps the high going longer.

As for mixing with methadone, as others said your issue before was precipitated withdrawals from buprenorphine which you won't get from oxy. But as for a "safe dose" no one can really tell you. You know what your opiate tolerance is, not us. I do recommend lowering your methadone dosage if you must take the oxy, and remember the golden rule: you can always take more but you can't take less.

If you want a rush from it then snorting is better than IV. If you IV oxy you get all the risks but none of the reward. Up the nose is the way to go. Start with a small line, give it some time to see how you feel, and go from there.
 
KS78 said:
Just opiates.
Click to expand...
ah this slightly made my morning, someone being able to know and distinguish opiates are different to opioids, nowadays everyone calls everything an opioid when thats incorrect
 
Zonxx said:
ah this slightly made my morning, someone being able to know and distinguish opiates are different to opioids, nowadays everyone calls everything an opioid when thats incorrect
Click to expand...

Calling an opiate an opioid is still correct. Opioid is just the more generic term in this context.

An opioid is any drug that is an agonist of the opioid receptors in the brain. Natural and semi-synthetic opiates, like morphine or oxycodone, are opioids because they meet the definition of an opioid. They're also opiates because they originate from the poppy.

On the other hand tramadol is an opioid but not an opiate, because while it does have opioid receptor agonism, it does not originate from the poppy.

So you can describe a natural or semi-synthetic opiate as either an opiate or opioid, both are correct, but a synthetic opioid is only an opioid not an opiate.
 
Wilson Wilson said:
There is seriously no point in trying to shoot oxy. It does not have a rush when IV'd and the oral BA is already high. If you want it to be fast hitting, the intranasal BA is only slightly lower and the rest goes into your stomach with the drip anyway.
Click to expand...

Though its been many years i recall it having a pretty decent rush, especially at high dose (2 oc80's IV'd comes on pretty strong).

But yes, don't shoot pills, and if you do, please use a micron filter.
 
If it is for the additive effect it would be fine in theory, and the relatively incomplete cross-tolerance and metabolic effects of both will probably lead to effects greater than the sum of the parts.

The other reason which other readers may have for combining two narcotics are that one has a rapid onset and the other lasts longer, like the common pain management method of combining IR hydromorphone or fentanyl lollipops with ER oxycodone, ER oxymorphone, ER morphine, methadone, levorphanol &c. Also scripting Opana with the IR tablets and/or the Numorphan ampoules; all three is a notably superior method -- IR for breakthrough pain expected to come, and kickstarting the ER in the morning, and Numorphan SC or IV for unexpected blasts of breakthrough pain. I actually had good effects from combining hydromorphone and levorphanol in a shot, the form in which they both came. There is much less reason for cooking up Levo-Dromoran tablets since the intravenous-oral ratio is 2:1, essentially the best of the strong narcotics, and the only one with a more favourable one, codeine, one should not be shooting anyways. Of course almost no one gets this lovely narcotic anymore since they are over US$100 a tablet because of that fucker Skhreli -- does anyone suppose he sucked dick to get drugs in the calaboose? He should have had to suck 20 dicks for a dose of anything or pay two cases of cigarettes for a codeine tab.
 
Shkreli got his hands on levorphanol? Perhaps not $100/pill but they do appear quite expensive

15157
 
negrogesic said:
Shkreli got his hands on levorphanol? Perhaps not $100/pill but they do appear quite expensive

View attachment 15157
Click to expand...

He was responsible for jacking up the price along with chemotherapy agents. It is like he was targeting cancer patients specifically.

Levorphanol is uniquely effective for certain kinds of pain because of the other receptors it hits. If someone is one of those people in the States, hopefully they can find a compounder or a pharmacology & medicinal chemistry professor at a place with a laboratory -- it is much less expensive to have them do a custom synthesis of levorphanol, and the racaemate is still CSA Schedule II and has DXO in it -- so getting just plain Dromoran might be the patient, doctor, pharmacist, and organic chemist's ace in the hole. It works better I can attest, and whilst the resolution of the enantiomers is not too horrifying, a bit more involved than the famously simple one with methadone, it is a step and expense which can be avoided.

What they need to do is make a powder put it in capsules with something else like DXM and/or tripelennamine, even sodium bicarbonate or Vitamin C, because of laws in many states that compounding pharmacists cannot make something which is already available as a proprietary (levorphanol tablets and ampoules) A university lab may in theory have an issue with FDA approval -- the idea is, do not sell it. Give it to the patient as part of an N of 1 study authorised and requested by the patient's GP or pain specialist and the department chairperson. And don't tell anybody,

It was up to $135 a tablet last spring actually.
 
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Holy shit the US medical system is fucked up... imagine typing your medication in and seeing you have to pay over a grand.

And this is very much unique to the US, I notice when I look up various pharmas even ones that aren't as stupidly high as $100 per pill, they're always more expensive in the US than anywhere else even when they're generics.

For example I believe generic diazepam is something like $3-5 per pill in the US. In the UK a box of 28 pills is £5-10. And almost no one pays even that because the NHS subsidises prescription cost. So for example I know generic dexamphetamine is around £80-100 per box of 28/30. I get a massive pile of the stuff from the pharmacy for £9 no matter what amount or dose I'm prescribed. £9 is the set price for any prescription.

Even with private prescriptions where you do pay the true price, and insurance does not cover outpatient prescriptions over here either, I got a diazepam script and paid £5 to get a box of 28 from the pharmacy. Of course when I tried that with my Vyvanse script they were saying it'd cost me £100 so I just made an appointment with my GP to get an NHS version printed out instead. But even that £100 for a bottle of Vyvanse is a lot less than you'd pay in the US considering it's a patented drug.
 
Wilson Wilson said:
For example I believe generic diazepam is something like $3-5 per pill in the US. In the UK a box of 28 pills is £5-10. And almost no one pays even that because the NHS subsidises prescription cost. So for example I know generic dexamphetamine is around £80-100 per box of 28/30. I get a massive pile of the stuff from the pharmacy for £9 no matter what amount or dose I'm prescribed. £9 is the set price for any prescription.
Click to expand...

Diazepam is dirt cheap in the US...

15197
 
What site is that? I'm curious to type a few meds into it and see how much they'd cost in the US. I'm especially interested in Vyvanse, dexamphetamine, and pregabalin.
 
Zonxx said:
ah this slightly made my morning, someone being able to know and distinguish opiates are different to opioids, nowadays everyone calls everything an opioid when thats incorrect
Click to expand...

I know...it's so simple, too!
Opium, Codeine, Morphine - Opiates
Everything else - Opioids
 
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