From what I have found, a larger amount of the studies, post 2000, seem to study Melatonin's nociceptive effect, and there are manytthat study/discuss an analgesia modulating effect. But there are clearly plenty that also that study its paradoxical hyperalgesic or proalgesic effect. Below are some studies that analyze or test the analgesic/nociceptive/hyperalgesic/proalgesic effects, or make use of its nociceptive effects...see below.
Melatonin in pain modulation: analgesic or proalgesic?
Y Liu, H He, F Huang - 2014 - 41.89.240.73
Melatonin, as an endogenous hormone produced mainly in the pineal gland in a clear circadian fashion, has diverse physiological functions, such as the control of circadian rhythms, sleep regulation, antioxidant, etc. Recently, accumulating researches about …
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Melatonin improves tourniquet tolerance and enhances postoperative analgesia in patients receiving intravenous regional anesthesia
HA Mowafi, SA Ismail - Anesthesia & Analgesia, 2008 - journals.lww.com
BACKGROUND: Melatonin has anxiolytic and potential analgesic effects. We assessed the efficacy of me.
Cited by 68 Related articles
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The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy
W Caumo, F Torres, NL Moreira, JAS Auzani… - Anesthesia & …, 2007 - journals.lww.com
BACKGROUND: Melatonin has sedative, analgesic, antiinflammatory, antioxidative, and chronobiotic eff.
Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat
SM El-Shenawy, OME Abdel-Salam,
AR Baiuomy… - Pharmacological …, 2002 - Elsevier
The present study aimed to evaluate the anti-inflammatory and anti-
nociceptive effects of
melatonin in the rat. Acute inflammation was induced by sub-plantar injection of carrageenan (1%) in the rat hind paw. The rats received vehicle or drug 30 min before …
Cited by 165 Related articles
Effects of melatonin, morphine and diazepam on formalin-induced nociception in mice
CS Pang, SF Tsang, JC Yang - Life sciences, 2001 - Elsevier
The possible analgesic effect of
melatonin was investigated in young male ICR mice. The formalin test which elicits typically 2 phases of
pain response, the acute (first) phase and tonic (second) phase, was used. The test was performed in the late light period when the …
Cited by 87 Related articles
Effect of melatonin on rat spinal cord nociceptive transmission
C Laurido, T Pelissier, R Soto-Moyano, L Valladares… - …, 2002 - journals.lww.com
Melatonin has been shown to exert potent antinociception but the sites and mechanisms of action underlying this effect have not yet been clarified. The effect of
melatonin on spinal cord
nociceptive transmission was studied in rats by assessing wid-up activity in a C-fiber …
Cited by 53 Related articles
Melatonin: a hormone that modulates pain
M Ambriz-Tututi, HI Rocha-González,
SL Cruz… - Life Sciences, 2009 - Elsevier
Aims
Melatonin is a hormone synthesized principally in the pineal gland that has been classically associated with endocrine actions. However, several lines of evidence suggest that
melatonin plays a role in
pain modulation. This paper reviews the available evidence on …
Cited by 187 Related article
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Melatonin reduces formalin-induced nociception and tactile allodynia in diabetic rats
R Arreola-Espino, H Urquiza-Marín… - European journal of …, 2007 - Elsevier
The purpose of this study was to assess the antinociceptive and antiallodynic effect of
melatonin as well as its possible mechanism of action in diabetic rats. Streptozotocin (50 mg/kg) injection caused hyperglycemia within 1 week. Formalin-evoked flinching was …
Cited by 60 Related articles
Evaluation of the anti-inflammatory and anti-nociceptive activities of novel synthesized melatonin analogues
GA Elmegeed,
AR Baiuomy… - European journal of …, 2007 - Elsevier
This study aimed at evaluation of the reactivity of
melatonin (1) towards various chemical reagents to produce new
melatonin analogues containing heterocyclic moieties which would provide basic pharmacological activities. The pyrrolo [1, 2-a] indole derivatives 3, 5 …
Cited by 47 Related articles
Melatonin replacement nullifies the effect of light-induced functional pinealectomy on nociceptive rhythm in the rat
TM John,
MC Brown,
L Wideman,
GM Brown - Physiology & behavior, 1994 - Elsevier
Rats maintained on a 12 h daily photoperiod (12: 12 LD cycle), exhibited a diunal variation in sensitivity to both heat-elicited and pressure-elicited
pain, with low sensitivity at 2 h before the end of the scotophase and higher at 4 h after the onset of photophase. Functional …
Cited by 35 Related articles
Pineal opioid receptors and analgesic action of melatonin
M Ebadi, P Govitrapong… - Journal of pineal …, 1998 - Wiley Online Library
… 3). The involvement of multiple receptors and mechanisms in
nociception … Analgesic action of
melatonin … There are many receptor subtypes that have been implicated in transmission of
nociceptive informa- tion in the dorsal horn, which include alpha-2 adrenoceptors, tachykinins …
Cited by 117 Related articles