Melanotan II

I read a comment on reddit/peptides before that 150 mcg should be sufficient for anyone and more is just a waste?

Any truth to this in anyone's experience?
 
For the sex drive, nothing I found works for it.

As for dosing, it's been a pretty strong curve in dose response. I notice significant tanning difference between 125, 250, 500, and 1000 mcg.
 
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Melanotan Mixing & Dosing Instructions

Reconstitution (mixing) This is the act of dissolving your freeze dried powder into a sterile liquid medium ready for injection or into a spray for nasal administation. This can be accomplished wit…
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MELANOTAN 2
Melanotan 2 has a half life of ~33 hours, this allows you to be very flexible with dosing.
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I had always believed that MT 2 half life was this.

However,

The half life of Melanotan 2 is one hour.
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skopemag.com

Learn About The Tanning Peptide Melanotan II And Its Side Effects

The injectable tanning peptide, Melanotan II is popularly used to gain a tan without being exposed to the ultraviolet solar radiation, sexual drive and to reduc
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.

peptide-guide.com

Melanotan 2

How to Use Melanotan Melanotan II analog of alpha-melanocyte stimulating hormone (a-MSH). Melanotan peptides are safe and efficacious with growing long term data. Melanotan 2 is a freeze dried peptide sealed in a sterile multi-use vial. Tanning injections of synthetic potent a-MSH allow for...
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I had always gone on the assumption the half life was in fact 36 hours.

However I began to question that recently, noticing how fast the side effects come on, and subsequently dissipate.


Most actual papers seem to suggest the 1 hour half life as being correct;

journals.plos.org

Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impaired social interactions, difficulty with communication, and repetitive behavior patterns. In humans affected by ASD, there is a male pre-disposition towards the condition with a male to female ratio of...
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MT2 Tmax on rats:

 
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Serotonin101 said:
For the sex drive, nothing I found works for it.

As for dosing, it's been a pretty strong curve in dose response. I notice significant tanning difference between 125, 250, 500, and 1000 mcg.
Click to expand...

Assuming you've actually dosed as high at 1 mg?

I've never gone over 500 mcg due to fear of side effects, that stomach cramping can suck (seems commonly enough reports on other sites).

However, other weird sides I was getting during the day seem to have been remarkably precluded by dosing MT2 at night - at least I dosed 250 last night and today all good.

Gonna try 500 tonight and all going well, may consider going higher to avail of potential tan benefits I couldn't get at 500.

Question being - 1 mg - I was under the impression most used 500 mcg as the top dose.

You've ran 1 mg frequently enough and nothing too sinister?
 
JohnBoy2000 said:
Assuming you've actually dosed as high at 1 mg?

I've never gone over 500 mcg due to fear of side effects, that stomach cramping can suck (seems commonly enough reports on other sites).

However, other weird sides I was getting during the day seem to have been remarkably precluded by dosing MT2 at night - at least I dosed 250 last night and today all good.

Gonna try 500 tonight and all going well, may consider going higher to avail of potential tan benefits I couldn't get at 500.

Question being - 1 mg - I was under the impression most used 500 mcg as the top dose.

You've ran 1 mg frequently enough and nothing too sinister?
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Correct. When I was a mt2 newb and believed in the whole loading phase I did 1mg/day for over a month. Last tanning phase (about 12 weeks ago) I ran 1mg/day for like 3 weeks to tan faster and darker. Idk what it is, but these days I don't really get the negative sides anymore after a couple days. Just the tan. Like day 3 or 4 of 1mg it doesn't affect appetite for me, no flushing feeling, just a slight warmth and that's it. Day 7 I feel like I might as well be injecting saline.
 
JohnBoy2000 said:
Just on half life vs biological effects.

I didn't read the paper itself but the statement is clear,

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https://www.sciencedirect.com/science/article/pii/S0378517398001495 (prob need to sci-hub that).

Anyone know, why and how it works like this?

i.e. biological effect substantially longer than its half life?

Half life reports are 36 hours, but that's more biological effect - but actual half life is about an hour.
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I'd imagine it's due to some sort of cascade effect from when it attaches to a melanocortin receptor and the effects afterwards. Kinda like the slow signaling in response to grehlin and the hunger response (we get full before our body actually "knows" that it's full)
 
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