Enix150
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Medical marijuana in treatment of certain brain diseases: Experts weigh in
April 28, 2014
A review by the American Academy of Neurology of available scientific
research on the use of medical marijuana in brain diseases finds certain
forms of medical marijuana can help treat some symptoms of multiple
sclerosis (MS), but do not appear to be helpful in treating drug-induced
(levodopa) movements in Parkinson's disease. Not enough evidence was
found to show if medical marijuana is helpful in treating motor problems
in Huntington's disease, tics in Tourette syndrome, cervical dystonia
and seizures in epilepsy. The review is published in the April 29, 2014,
print issue of Neurology?, the medical journal of the American Academy
of Neurology (AAN), and will be presented at the AAN Annual Meeting in
Philadelphia, April 26-May 3, 2014, which is the world's largest
gathering of neurologists.
"This review by the world's largest association for neurologists is
intended to help neurologists and their patients understand the current
research on medical marijuana for the treatment of certain brain
diseases," said review author Barbara S. Koppel, MD, of New York Medical
College in New York and Fellow of the American Academy of Neurology.
"The AAN review also highlights the need for more high-quality studies
of the long-term efficacy and safety of medical marijuana in the
treatment of neurologic diseases."
The AAN review concluded that certain forms of medical marijuana (only
in pill or oral spray form) can help treat some symptoms of MS. These
include spasticity, certain types of pain (pain related to spasticity,
including painful spasms, and painful burning and numbness) and
overactive bladder.
Most of the MS studies examined pill or oral spray forms of medical
marijuana. There were two studies that examined smoked medical marijuana
for treating MS symptoms. However, the studies did not provide enough
information to show if smoked medical marijuana is effective. "It's
important to note that medical marijuana can worsen thinking and memory
problems, and this is a concern since many people with MS suffer from
these problems already due to the disease itself," said Koppel.
For Parkinson's disease, the AAN review concluded that medical marijuana
in the form of synthetic tetrahydrocannabinol (THC) pills likely does
not help relieve abnormal movements that can develop in the late stages
of the disease from the drug levodopa, which is the main drug used to
treat shaking, stiffness and slowness of movements.
The AAN review also concluded that there is not enough information to
show if medical marijuana, including smoked medical marijuana, is safe
or effective in these neurologic diseases: ? Motor symptoms in
Huntington's disease ? Tics in Tourette syndrome ? Cervical dystonia
(abnormal neck movements) ? Seizures in epilepsy
There are safety concerns with medical marijuana use. Side effects
reported in at least two studies were nausea, increased weakness,
behavioral or mood changes, suicidal thoughts or hallucinations,
dizziness or fainting symptoms, fatigue, and feelings of intoxication.
There was one report of a seizure.
Mood changes and suicidal thoughts are of special concern for people
with MS, who are at an increased risk for depression or suicide. The
studies showed the risk of serious psychological effects is about 1
percent, or one in every 100 people.
In general, medical marijuana is prescribed as a treatment for use only
when standard treatment has not helped.
April 28, 2014
A review by the American Academy of Neurology of available scientific
research on the use of medical marijuana in brain diseases finds certain
forms of medical marijuana can help treat some symptoms of multiple
sclerosis (MS), but do not appear to be helpful in treating drug-induced
(levodopa) movements in Parkinson's disease. Not enough evidence was
found to show if medical marijuana is helpful in treating motor problems
in Huntington's disease, tics in Tourette syndrome, cervical dystonia
and seizures in epilepsy. The review is published in the April 29, 2014,
print issue of Neurology?, the medical journal of the American Academy
of Neurology (AAN), and will be presented at the AAN Annual Meeting in
Philadelphia, April 26-May 3, 2014, which is the world's largest
gathering of neurologists.
"This review by the world's largest association for neurologists is
intended to help neurologists and their patients understand the current
research on medical marijuana for the treatment of certain brain
diseases," said review author Barbara S. Koppel, MD, of New York Medical
College in New York and Fellow of the American Academy of Neurology.
"The AAN review also highlights the need for more high-quality studies
of the long-term efficacy and safety of medical marijuana in the
treatment of neurologic diseases."
The AAN review concluded that certain forms of medical marijuana (only
in pill or oral spray form) can help treat some symptoms of MS. These
include spasticity, certain types of pain (pain related to spasticity,
including painful spasms, and painful burning and numbness) and
overactive bladder.
Most of the MS studies examined pill or oral spray forms of medical
marijuana. There were two studies that examined smoked medical marijuana
for treating MS symptoms. However, the studies did not provide enough
information to show if smoked medical marijuana is effective. "It's
important to note that medical marijuana can worsen thinking and memory
problems, and this is a concern since many people with MS suffer from
these problems already due to the disease itself," said Koppel.
For Parkinson's disease, the AAN review concluded that medical marijuana
in the form of synthetic tetrahydrocannabinol (THC) pills likely does
not help relieve abnormal movements that can develop in the late stages
of the disease from the drug levodopa, which is the main drug used to
treat shaking, stiffness and slowness of movements.
The AAN review also concluded that there is not enough information to
show if medical marijuana, including smoked medical marijuana, is safe
or effective in these neurologic diseases: ? Motor symptoms in
Huntington's disease ? Tics in Tourette syndrome ? Cervical dystonia
(abnormal neck movements) ? Seizures in epilepsy
There are safety concerns with medical marijuana use. Side effects
reported in at least two studies were nausea, increased weakness,
behavioral or mood changes, suicidal thoughts or hallucinations,
dizziness or fainting symptoms, fatigue, and feelings of intoxication.
There was one report of a seizure.
Mood changes and suicidal thoughts are of special concern for people
with MS, who are at an increased risk for depression or suicide. The
studies showed the risk of serious psychological effects is about 1
percent, or one in every 100 people.
In general, medical marijuana is prescribed as a treatment for use only
when standard treatment has not helped.
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