AnonymousAbuser
Bluelighter
- Joined
- Oct 16, 2013
- Messages
- 188
If I were to take MDMA 1 week after using 25i, would I have anything to worry about? Would this lessen the effects of the MDMA? I am having trouble finding any information on this topic.
In my experience you will have tolerance from the 25i. It also depends on how much 25i you took, but your MDMA trip should be weaker. Your mileage may vary though.
I would take the 25i after the MDMA. A wasted roll is AWFUL, but some wasted 25i? Who gives a fuck when you can get 100 hits for less than the price of a carton of cigarettes
25i seems to have VERY strong tolerance to other serotonergic drugs. In fact I've actually never really seen a drug with such strong, long-lasting and wide-reaching tolerance
i did mdma 1 week after a strong 25i trip....it was my first mdma use in around a year, it was the best roll of my life.
25i seems to have VERY strong tolerance to other serotonergic drugs. In fact I've actually never really seen a drug with such strong, long-lasting and wide-reaching tolerance
Activation of the 5-HT2A receptor is necessary for the effects of the "classic" psychedelics like LSD, psilocin and mescaline, which act as full or partial agonists at this receptor, and represent the three main classes of 5-HT2A agonists, the ergolines, tryptamines and phenethylamines, respectively. A very large family of derivatives from these three classes has been developed, and their structure-activity relationships have been extensively researched.[27][28] Agonists acting at 5-HT2A receptors located on the apical dendrites of pyramidal cells within regions of the prefrontal cortex are believed to mediate hallucinogenic activity. Newer findings reveal that psychoactive effects of classic psychedelics are mediated by the receptor heterodimer 5-HT2A–mGlu2 and not by monomeric 5-HT2A receptors.