No. 13 Baby
Bluelighter
- Joined
- Feb 22, 2011
- Messages
- 330
bump for MDMA + DMT
i smoked DMT while coming down from rolling and had one of the most introspective trips in my life. i actually wrote about it here on BL.
it killed the comedown and put me to sleep .
i wouldn't say it was negative
scary, fuck yeah
Apparently MDMA reduces the chance of getting a bad trip on DMT.
I've heard it increases the neurotoxicity of MDMA?
Where did you hear that? Never heard of tryptamines increasing the speculated(?) MDMA neurotoxicity, apart from possibly the likes of AMT/similar.
MDMA neurotoxicity was completely prevented by pre-treatment with a 5-HT(2A)-receptor antibody,
mdma's 5-ht2a agonism is definitely the cause of its neurotoxicity:
However, it has to be said that
(I) neurotoxcity only happens at the human equivalent of at least 400mg mdma in one go (but actually more like 800mg in one go)
(II) tryptamines are generally also 5-ht1a agonists, which antagonizes their neurotoxic 5-ht2a effects, since 5-ht1a agonists are neuroprotective, because they reduce glutamatergic neurotransmission, while 5-ht2a agonists increase it
source:
Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons.
That sucks because I thought MDMA would be good for reducing my fear