Jabberwocky
Frumious Bandersnatch
- Joined
- Nov 3, 1999
- Messages
- 84,998
Apparently there are actually a lot of CYP enzymes that contribute to the metabolism of MDMA:
CYP1A2
CYP2B6 (n-demethylation)
CYP2D6 (clearance)
CYP2D19
CYP3A4
And apparently all but 1A2 and 3A4 are enantioselective in metabolizing MDMA (they metabolize one isomer preferentially)
https://www.ncbi.nlm.nih.gov/pubmed/18725511
There are multiple polymorphisms in CYP in humans, as the dose increases, the effect of:
individual polymorphisms,
enantioselective CYP enzymes,
CYP inhibitors (fluconazole all but 1A2 and 2B6) not expected to impact MDXX metabolism
-- could easily lead to an enantiomeric excess even though the original substance is a (50/50) racemic mix
CYP1A2
CYP2B6 (n-demethylation)
CYP2D6 (clearance)
CYP2D19
CYP3A4
And apparently all but 1A2 and 3A4 are enantioselective in metabolizing MDMA (they metabolize one isomer preferentially)
https://www.ncbi.nlm.nih.gov/pubmed/18725511
There are multiple polymorphisms in CYP in humans, as the dose increases, the effect of:
individual polymorphisms,
enantioselective CYP enzymes,
CYP inhibitors (fluconazole all but 1A2 and 2B6) not expected to impact MDXX metabolism
-- could easily lead to an enantiomeric excess even though the original substance is a (50/50) racemic mix