mdma bioavailibity

[farmacista]

there aren't any studies about mdma's bioavailibity when is taken orally? and when is snorted?

 

[pofacedhoe]

look up caffeine and mdma absorbtion

 

[farmacista]

mh wasn't useful

 

[farmacista]

i was looking for mdma's bioavailability not interaction

 

[sekio]

There aren't, it seems.

Oral BA is variable based on dose. Bigger doses are better absorbed.

Given that a "good oral dose" is considered to be about 120mg, and comparable injected doses anecdotally are about 25-50mg, that means it's probably something like...

oral: 30-60%
nasal/rectal: 60-80%

 

[farmacista]

no, don't think nasal is higher rhan oral...how is it possible?

 

[sekio]

Lots of drugs have higher BA via non-oral routes, because orally administerred medications have to be processed by your liver before they make it into your blood, resulting in a loss of drug.

Anecdotally, most people who do nasal/rectal MDMA report they have to use less than they'd use if they did it orally.