This is an interesting concept...and some responses kind of answer something I could never figure out
I took E on two occasions with someone who has been diagnosed with antisocial personality disorder (sociopath). Both times I was high off it...the usual feelings. He on the other hand both times (different stuff, taken months apart from different sources) claimed the pills were garbage n he got ripped off !?! I didn't get it at all. But now, reading this thread, I understand what may very well have been the reason: empathetic drug not having effect on his brain. Well at least now I understand how I could be rolling off the same stuff he claimed "didn't work"
Oh that is good to hear...I was concerned I might be a sociopath, but when I have taken E/MDMA I definitely rolled and it was a great time.