Ive taken quite a lot of lyrica over the years! I mainly use it when i dont have access to other GABA drugs, i find it helps with my anxiety & sometimes i take it recreationally to potentate other downers. I also find it handy when im coming down & so on.
Anyways after a recent experience where i took it at the tail end of a meth bender, it resulted in me having a grand mal seizure, i dont have a history of seizures & the only other seizure ive had in my life was about 12 months earlier & lyrica was also involved. The first time id had 600mg over the course of 12 hours split into 2 doses, combined with alcohol, ketamine & MDMA. The seizure occurred about 45 minutes after consuming the ketamine. I summed it up to an interaction between ketamine & lyrica.... i continued taking lyrica after that event with no issues until last week.
This time around id been awake smoking meth for id say between 48 to 60 hours probably about 3 points over that time & decided it was time to wind down pop some downers & relax in bed playing ps3, my last memory is taking a final 150mg cap to take my dose up to 450mg, the next thing im awaking confused to paramedics in my bedroom informing me ive just had a seizure & been unresponsive for some time.
Im a bit confused as to what exactly has caused these two incidents, the lyrica is obviously a contributing factor but this is a drug i have quite a lot of experience with & both times i was not using it excessively (in my standards) or more than a couple of times a week at the most. I dont have a dependency to GABA drugs either. The best theory i can come up with is i guess a "perfect storm" kind of scenario between the lyrica, dehydration & low blood sugar from not eating, combined with the stimulant type drugs (meth/mdma) causing further strain, lack of sleep etc.
So before i finished writing this post i had a quick look into the pharmacodynamics of Lyrica to discover it does not bind directly to GABA receptors..... Anyways thats my story! Think ill steer clear of it for a while & stick to benzos or phenibut & if i do decide to take it make sure im well hydrated & not so disheveled.