I used to dissolve my pregabalin in juice, doses of 600mg-900mg; pretty weird, chemical sorta taste but I don't recall it having any signfificant advantage to simply swallowing in-capsule. In fact, I think that it might even help for pregabalin to be more slowly transported into the system; I used to get stronger effects if I took say, 3 divided doses of 300mg rather than 900mg in one whack. Pregabalin seems to share basically none of the pharmokinetics of gabapentin eg. it does not absorb better with food/fatty food or whatever, but I do think it has some of the transporter-saturation effect especially at very high doses.
Either way, the w/d is hideous IME, and high doses for prolonged periods make me whacky as fuck so I just take 150mg x 3 per day and get some anxiety and pain relief from it. Higher doses now and then are enjoyable but tolerance rises incredibly rapidly and completely on this stuff.